{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:30:03Z","timestamp":1777386603471,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-B-109010"],"award-info":[{"award-number":["TSGH-B-109010"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-D-109053"],"award-info":[{"award-number":["TSGH-D-109053"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2314-B-016-037"],"award-info":[{"award-number":["MOST 108-2314-B-016-037"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Obstructive sleep apnea is associated with an increased risk of male infertility, and one of its causes is deviated nasal septum with inferior turbinate hypertrophy (DNS\/ITH). However, the risk of male infertility associated with DNS\/ITH remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Taiwan Longitudinal Health Insurance Database, we conducted a retrospective matched cohort study to investigate the risk of infertility in male patients diagnosed with DNS\/ITH (N\u2009=\u200961,761) from 2000 to 2015 in comparison with matched controls without DNS\/ITH (N\u2009=\u2009247,044). We further analyzed the effect of septoturbinoplasty (STP), including septoplasty and turbinoplasty, on the risk of male infertility in DNS\/ITH patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the end of the follow-up period, 46 (0.07%, 46\/61,761, incidence rate: 6.25 per 100,000 person-years) patients developed infertility in the DNS\/ITH group versus 72 (0.03%, 72\/247,044, incidence rate: 2.28 per 100,000 person-years) in the control group; the incidence rate was 2.740-fold higher in the DNS\/ITH group (log-rank P\u2009&lt;\u20090.001). Cox proportional hazards regression revealed that the risk of infertility increased in the DNS\/ITH group [adjusted hazard ratio (HR): 1.080, 95% confidence interval (CI), 1.049\u20131.514, P\u2009=\u20090.001]. Compared with the control group, the risk of infertility was highest in the DNS\/ITH group without STP (adjusted HR: 2.842, 95% CI, 1.715\u20134.082, P\u2009&lt;\u20090.001), followed by the DNS\/ITH group with STP (adjusted HR: 1.074, 95% CI, 1.035\u20131.488, P\u2009=\u20090.012). The intervention of STP reduced the risk of infertility in the DNS\/ITH group by 45.1% compared with those without STP (P\u2009=\u20090.033).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinicians should be aware of the risk of infertility in male patients presenting with DNS\/ITH. Improving the nasal airway by STP may decrease the risk of male infertility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1945892420932485","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T01:23:47Z","timestamp":1592443427000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Deviated Nasal Septum With Inferior Turbinate Hypertrophy and the Risk of Male Infertility"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-5621","authenticated-orcid":false,"given":"Hsin-Chien","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Hsiang","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan"},{"name":"School of Public Health, National Defense Medical Center, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu-Chien","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan"},{"name":"School of Public Health, National Defense Medical Center, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"bibr1-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2018.20"},{"key":"bibr2-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2018.07.006"},{"key":"bibr3-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.08.006"},{"key":"bibr4-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-010-0373-0"},{"key":"bibr5-1945892420932485","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4166"},{"key":"bibr6-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1469-7"},{"key":"bibr7-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2018.05.012"},{"key":"bibr8-1945892420932485","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-2173"},{"key":"bibr9-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2016.07.002"},{"key":"bibr10-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6815-14-11"},{"key":"bibr11-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.0246"},{"key":"bibr12-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.09.009"},{"key":"bibr13-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.09.017"},{"key":"bibr14-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215119001798"},{"key":"bibr15-1945892420932485","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2009.30.3244"},{"key":"bibr16-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.08.001"},{"key":"bibr17-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2018.05.008"},{"key":"bibr18-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/929285"},{"key":"bibr19-1945892420932485","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000229953.76862.e5"},{"key":"bibr20-1945892420932485","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.107.003731"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1945892420932485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1945892420932485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1945892420932485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:36:41Z","timestamp":1777369001000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1945892420932485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/1945892420932485"],"URL":"https:\/\/doi.org\/10.1177\/1945892420932485","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,17]]}}}