{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:05:37Z","timestamp":1793325937057,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) often requires surgery, but recurrence even after surgery is common. Recurrence rates largely vary in literature and asthma seems to be a comorbid factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we aim to estimate disease recurrence during a long-term follow-up, together with the investigation of possible predicting and\/or influencing parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Out of 196 patients operated for CRSwNP between 01\/2000 and 01\/2006, 133 patients had a follow-up of at least 10 years and could be included. The inflammatory profile at surgery was determined on nasal tissue and sinonasal secretions, and included analysis of eosinophils, eosinophilic-rich mucus (ERM) typically containing Charcot-Leyden crystals (CLC), and fungal hyphae (FH). During follow-up, recurrence, received treatments and comorbidities were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of the 133 included patients, local eosinophilia was present in 81% and ERM in 60%. Recurrence during follow-up was observed in 62%, and was associated with local eosinophilia and ERM (both p\u2009&lt;\u20090.001). Asthma was present in 28% at inclusion, and 17% developed asthma after surgery during follow-up. The presence of asthma, at inclusion as well as developed during follow-up, was significantly associated with recurrence of CRSwNP (p\u2009=\u20090.001 for group comparison).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Recurrence after CRSwNP surgery is common when a long-term follow-up is taken into account. ERM detected in sinonasal secretions at surgery seems to be a predictive factor for recurrence and need for revision surgery. Asthma is a frequently found comorbid factor in CRSwNP, develops even at higher age despite surgical treatment for CRSwNP, and is also associated with a higher recurrence rate. Sustained medical care after surgery is mandatory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1945892420961964","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:54:59Z","timestamp":1601945699000},"page":"449-457","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Surgery in Nasal Polyp Patients: Outcome After a Minimum Observation of 10 Years"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-046X","authenticated-orcid":false,"given":"Stephan","family":"Vlaminck","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, AZ St-Johns Hospital, Bruges, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Acke","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Prokopakis","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Crete School of Medicine, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kato","family":"Speleman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, AZ St-Johns Hospital, Bruges, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Kawauchi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"van Cutsem","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, AZ St-Johns Hospital, Bruges, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Hellings","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Jorissen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Seys","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut Van","family":"Zele","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N.","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation, VIB Center for Inflammation Research, Ghent, Belgium"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium"},{"name":"Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gevaert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"bibr1-1945892420961964","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"bibr2-1945892420961964","first-page":"1","volume":"3","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"bibr3-1945892420961964","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.010"},{"key":"bibr4-1945892420961964","doi-asserted-by":"crossref","unstructured":"Lange B, Holst R, Thilsing T, Baelum J, Kjeldsen A. \nQuality of life and associated factors in persons with chronic rhinosinusitis in the general population: a prospective questionnaire and clinical cross-sectional study. 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