{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:15:51Z","timestamp":1784740551998,"version":"3.55.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Novartis Farmaceutica S.A., (Spain)."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a clinical entity with specific features that impacts significantly on patient quality of life (QoL). CRSwNP is often associated with asthma and is difficult to control and manage despite pharmacological and\/or surgical treatment. Omalizumab, a monoclonal anti-IgE antibody, has emerged as a putative therapeutic option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of omalizumab on nasal polyp (NP) size and QoL assessed by Sino-Nasal Outcome Test-22 (SNOT-22) in patients with recalcitrant CRSwNP and mild asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter retrospective analysis of patient data from the Community of Valencia (Spain) was performed. Adult patients with recalcitrant CRSwNP and comorbid mild asthma receiving compassionate use of omalizumab were included. NP size measured by total nasal endoscopic polyp score (TPS) and QoL evaluated through the SNOT-22 questionnaire were assessed at baseline and monthly over 12\u2009months. An ordinal regression model was built to analyze the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 23 CRSwNP patients with a mean age (\u00b1 SD) of 54.78\u2009\u00b1\u20099.46\u2009years were included. Nineteen suffered from aspirin-exacerbated respiratory disease (AERD). In all patients, a significant and sustained reduction in TPS was observed over time, accompanied by improvements in QoL reflected in lower SNOT-22 scores. In the ordinal regression model, time but not total IgE, age or tissue eosinophilia impacted on NP size and SNOT-22 outcomes. Additionally, improvements in QoL were not explained by reductions in the size of polyps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Omalizumab was effective for the treatment of patients with recalcitrant CRSwNP and mild asthma, even when AERD was present, by reducing NP size and improving QoL; treatment time was a key factor. SNOT-22 improvements were not explained by decreases in TPS, indicating that omalizumab may be effective in all patients, regardless of polyp size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1945892420972326","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T21:00:00Z","timestamp":1604696400000},"page":"516-524","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of Omalizumab Treatment in Patients With Recalcitrant Nasal Polyposis and Mild Asthma: A Multicenter Retrospective Study"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8258-6292","authenticated-orcid":false,"given":"Miguel","family":"Armengot-Carceller","sequence":"first","affiliation":[{"name":"Otolaryngology Department, University and Polytechnic La Fe Hospital, Valencia, Spain"},{"name":"Department of Surgery, Valencia University, Valencia, Spain"},{"name":"Grupo de Biomedicina Molecular, Celular y Gen\u00f3mica (BMCG), Health Research Institute La Fe, Valencia, Spain"},{"name":"CIBER of Respiratory Diseases, Instituto de Salut Carlos III, Ministerio de Ciencia e Innovaci\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"G\u00f3mez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Otolaryngology Department, University and Polytechnic La Fe Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Garc\u00eda-Naval\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Surgery, Valencia University, Valencia, Spain"},{"name":"Otolaryngology Department, University General Hospital of Valencia, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encarna","family":"Dom\u00e9nech-Campos","sequence":"additional","affiliation":[{"name":"Otolaryngology Department, Arnau de Vilanova Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-4827","authenticated-orcid":false,"given":"Noelia","family":"Mu\u00f1oz-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Otolaryngology Department, University and Polytechnic La Fe Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa Garc\u00eda-Lliber\u00f3s de","family":"Miguel","sequence":"additional","affiliation":[{"name":"Otolaryngology Department, Manises Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Marco-Algarra","sequence":"additional","affiliation":[{"name":"Department of Surgery, Valencia University, Valencia, 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