{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:36:48Z","timestamp":1788565008617,"version":"build-2803163510"},"reference-count":62,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82000954"],"award-info":[{"award-number":["82000954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Hospitals Authority Clinical Medicine Development of Special Funding","award":["XMLX202136"],"award-info":[{"award-number":["XMLX202136"]}]},{"name":"Beijing Hospitals Authority Youth Program","award":["QML20190617"],"award-info":[{"award-number":["QML20190617"]}]},{"name":"Beijing Science and Technology Nova Program","award":["Z201100006820086"],"award-info":[{"award-number":["Z201100006820086"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nasal sprays with corticosteroids deliver medication to the restricted areas including anterior and inferior parts of the nasal cavity. The fluticasone exhalation delivery system (EDS-FLU) has recently been proved to improve care by increasing superior\/posterior intranasal corticosteroid deposition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to evaluate the efficacy of EDS-FLU in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A systematic literature review using Pubmed, Embase, Cochrane Library, and Web of Science was conducted to identify studies assessing the effect of EDS-FLU on outcomes in patients with CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the initial 108 abstracts reviewed, 4 full-text articles were included. The 22-item sinonasal outcome test scores were significantly decreased in patients with CRSwNP after receiving EDS-FLU twice a day (93, 186, or 372\u2005\u03bcg) for 16 weeks when compared with exhalation delivery system (EDS)-placebo (all P\u2009&lt;\u2009.001). Patients with CRSwNP reported significant improvement of smell after receiving twice daily EDS-FLU twice a day (93, or 372\u2005\u03bcg) for 4 weeks when compared with EDS-placebo (all P\u2005&lt;\u2009.05). The proportions of patients achieving \u22651-point improvement in total polyp grade were significantly higher in EDS-FLU group and dose dependent, with the highest rates in the 372\u2005\u03bcg group. The proportions of patients achieving polyp elimination were significantly higher in EDS-FLU group with the highest rates in the 372\u2005\u03bcg group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first systematic review of the clinical outcomes in patients with CRSwNP treated with EDS-FLU. EDS-FLU produced significant improvements regarding the quality of life, smell, and endoscopic assessment of polyp grade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924211033214","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T10:20:13Z","timestamp":1627986013000},"page":"176-184","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Fluticasone Exhalation Delivery System in Patients With Chronic Rhinosinusitis With Nasal  Polyps: A Systematic Review"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4888-3255","authenticated-orcid":false,"given":"Dawei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 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