{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:44:00Z","timestamp":1785807840130,"version":"3.56.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["R01 RR021746"],"award-info":[{"award-number":["R01 RR021746"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA2014"],"award-info":[{"award-number":["P30 CA2014"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Background: Comorbid chronic rhinosinusitis (CRS) of adulthood is increasing among patients with cystic fibrosis (CF) due to improved median survival. However, little is known about the natural history of endoscopic sinus surgery (ESS) in this cohort. The objective of this study was to evaluate the revision rate of ESS and associated risk factors among adults with CRS and CF (CRSwCF). Methods: The Utah Population Database was queried for patients age &gt;18 with CRS who underwent at least one ESS between 1996 and 2018. Demographic information and ESS history were collected and compared for CRSwCF versus CRS without CF (CRSsCF) using chi-square and t-tests. Risk factors for revision were analyzed using Cox proportional hazard models and logistic regression analysis. Results: A total of 34\u00a0050 patients (33\u00a0639 CRSsCF and 411 CRSwCF) were included in the final analysis. The mean duration of follow-up was 9.3 and 9.3 years, respectively ( P\u2009=\u2009.98). Adult patients with CF were significantly more likely to undergo revision ESS (18.7%) than those without CF (13.4%; P\u2009&lt;\u2009.01). Logistic regression analysis indicated that a diagnosis of CF independently elevated the risk for revision ESS in the absence of nasal polyps (odds ratio [OR] 2.18, confidence interval [CI] 1.34-3.54), asthma (OR 1.36, CI 0.94-1.98), and allergies (OR 1.29, CI 0.90-1.73). Conclusion: In the era before highly effective modulator therapies, the mean revision rate of ESS among adults with CRSwCF was 18.7%, significantly greater than that of adults with CRSsCF. CF was an independent risk factor for revision ESS in the absence of nasal polyps, asthma, and allergies.<\/jats:p>","DOI":"10.1177\/19458924211046719","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T13:55:23Z","timestamp":1634738123000},"page":"222-228","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Cystic Fibrosis Increases Long-Term Revision Rates of Endoscopic Sinus Surgery in Patients With Comorbid Chronic Rhinosinusitis"],"prefix":"10.1177","volume":"36","author":[{"given":"Kristine A.","family":"Smith","sequence":"first","affiliation":[{"name":"University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarbir S.","family":"Gill","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Beswick","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong","family":"Meeks","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-2200","authenticated-orcid":false,"given":"Gretchen M.","family":"Oakley","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Yim","sequence":"additional","affiliation":[{"name":"Louisiana State University Shreveport, Shreveport, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Curtin","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"},{"name":"University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Orlandi","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-5028","authenticated-orcid":false,"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"issue":"5","key":"bibr1-19458924211046719","first-page":"634","volume":"14","year":"2016","journal-title":"J Natl Compr Canc Netw"},{"key":"bibr2-19458924211046719","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21252"},{"key":"bibr3-19458924211046719","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24503"},{"key":"bibr4-19458924211046719","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.810"},{"key":"bibr5-19458924211046719","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino.11.271"},{"key":"bibr6-19458924211046719","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202004-0999LE"},{"key":"bibr7-19458924211046719","unstructured":"Cystic Fibrosis Foundation Patient Registry, 2016 Annual Report. Bethesda, MD:61."},{"key":"bibr8-19458924211046719","unstructured":"Utah Population Database. 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