{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:14:50Z","timestamp":1789578890719,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009886","name":"Regione Puglia","doi-asserted-by":"publisher","award":["Progetto Strategico Regione Puglia grant (E.R., 2"],"award-info":[{"award-number":["Progetto Strategico Regione Puglia grant (E.R., 2"]}],"id":[{"id":"10.13039\/501100009886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016112","name":"Universit\u00e0 degli Studi di Foggia","doi-asserted-by":"publisher","award":["University Research Projects 2019 \u201cPRA 2019\u201d g"],"award-info":[{"award-number":["University Research Projects 2019 \u201cPRA 2019\u201d g"]}],"id":[{"id":"10.13039\/100016112","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministero dell'Istruzione, dell'Universit\u00e0 e della Ricerca","award":["FIRB \u201cCAROMICS\u201d granted to E.R., 2011"],"award-info":[{"award-number":["FIRB \u201cCAROMICS\u201d granted to E.R., 2011"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is typically characterized by Type 2 inflammation. Several biomarkers of eosinophilic inflammation, including Galectin-10, also known as Charcot-Leyden crystal protein (CLCP), have been identified to establish eosinophilic infiltration of polyps, a reliable predictor of recurrence. Objective: We aimed to evaluate the Galectin-10 expression in nasal polyps of patients with CRSwNP and to assess the correlation of Charcot-Leyden crystals expression to the severity of CRSwNP according to Clinical-Cytological Grading (CCG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A double-label immunofluorescence was performed to evaluate the expression of Gal-10, CD15, Tryptase, and CD63 and their eventual co-localization on histological samples of 18 patients with CRSwNP. Double-positive Gal-10+CD15+ and Galectin-10+Tryptase+ inflammatory cells were counted by confocal microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Galectin-10 was detectable in all examined tissues from CRSwNP patients, and its expression increased as low, medium and high CCG tissues were examined, respectively. Galectin-10 was extensively present in inflammatory cells, while limited Galectin-10 deposits were detected around mucosal epithelial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We showed the strong correlation between CCG and Galectin-10 expression, mainly colocalized with infiltrating eosinophils and mast-cells, in patients affected by CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924211049867","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T06:03:15Z","timestamp":1634191395000},"page":"229-237","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Chronic rhinosinusitis with nasal  polyposis (CRSwNP): the correlation between expression of Galectin-10 and Clinical-Cytological Grading (CCG)"],"prefix":"10.1177","volume":"36","author":[{"given":"Matteo","family":"Gelardi","sequence":"first","affiliation":[{"name":"Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Stefano","family":"Netti","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pathology and Center for Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5082-7271","authenticated-orcid":false,"given":"Rossana","family":"Giancaspro","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Spadaccino","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pathology and Center for Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pennella","sequence":"additional","affiliation":[{"name":"Unit of Pathology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Fiore","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"La Gatta","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi Mariano","family":"Grilli","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cassano","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ranieri","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pathology and Center for Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"bibr1-19458924211049867","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S290424"},{"key":"bibr2-19458924211049867","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000588"},{"key":"bibr3-19458924211049867","doi-asserted-by":"crossref","unstructured":"Stevens W. W.\n                      et al\n                      . Associations Between Inflammatory Endotypes and Clinical Presentations in Chronic Rhinosinusitis.\n                      J. Allergy Clin. Immunol. Pract\n                      .\n                      7\n                      , 2812\u20132820.e3 (2019).","DOI":"10.1016\/j.jaip.2019.05.009"},{"key":"bibr4-19458924211049867","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211009429"},{"key":"bibr5-19458924211049867","volume":"11","author":"Gan W.","year":"6364","journal-title":"Sci. Rep"},{"key":"bibr6-19458924211049867","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2021.13.3.363"},{"key":"bibr7-19458924211049867","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw4295"},{"key":"bibr8-19458924211049867","first-page":"1","author":"Zhang M.","year":"2020","journal-title":"Int. Arch. 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