{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:36:29Z","timestamp":1793136989986,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100001607","name":"Eye and Ear Foundation of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001607","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Tinker Project"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fractional exhaled nitric oxide (FeNO) is a cost-effective, noninvasive point-of-care test that has proven valuable in identifying patients with lower airway inflammation and predicting the likelihood of responsiveness to inhaled corticosteroid therapy in asthma. The utility of FeNO in upper airway disease, specifically in CRS, remains to be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal of this study was to test whether FeNO could serve as a noninvasive marker of sinonasal mucosal inflammation in CRS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>FeNO was obtained using a nitric oxide analyzer (NIOX VERO) as well as nasal mucus, the 22-item Sinonasal Outcome Test (SNOT-22), University of Pennsylvania Smell Identification Test (UPSIT), and Lund-Kennedy endoscopic scores concurrently in 112 CRS patients. Nasal mucus was analyzed for cytokine expression using solid-phase sandwich ELISA. Linear regression with Spearman correlation coefficient was used to determine strength of relationship between variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CRS patients showed elevated FeNO levels with asthma (47.12\u2009\u00b1\u20095.21\u2005ppb) or without asthma (43.24\u2009\u00b1\u20099.810\u2005ppb). Elevated FeNO levels correlated with sinonasal mucosal inflammation, as determined by increased levels of CCL26 and TNF\u03b1 in nasal mucus obtained from CRS patients. Furthermore, elevated FeNO levels selectively correlated with worsened SNOT-22 nasal symptoms (P\u2009=\u20090.03) and Lund-Kennedy endoscopic scores (P\u2009=\u20090.007), but did not correlate with UPSIT scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FeNO levels correlated with increased sinonasal mucosal inflammation and symptom severity in CRS regardless of asthma status. FeNO measurements may serve as a quick and noninvasive marker in evaluating CRS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924221080260","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T10:50:41Z","timestamp":1646304641000},"page":"465-472","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Fractional Exhaled Nitric Oxide as a Marker of Mucosal Inflammation in Chronic Rhinosinusitis"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-3409","authenticated-orcid":false,"given":"Tolani F.","family":"Olonisakin","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2009\u2013\u2009Head & Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Barel","sequence":"additional","affiliation":[{"name":"School of Medicine, Lake Erie College of Osteopathic Medicine (LECOM), Erie, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bliss","family":"Uribe","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana M.","family":"Parker","sequence":"additional","affiliation":[{"name":"School of Biology, Washington & Jefferson College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve M. R.","family":"Bowers","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed M.","family":"Nouraie","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Allergy and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally E.","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Department of Environmental & Occupational Health"},{"name":"University of Pittsburgh Asthma and Environmental Lung Health Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"bibr1-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.82"},{"key":"bibr2-19458924221080260","doi-asserted-by":"crossref","unstructured":"Succar EF, Turner JH. Recent advances in understanding chronic rhinosinusitis endotypes [version 1; peer review: 2 approved]. F1000Research. 2018;7(F1000 Faculty Rev):1909. (https:\/\/doi.org\/10.12688\/f1000research.16222.1).","DOI":"10.12688\/f1000research.16222.1"},{"key":"bibr3-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.05.004"},{"key":"bibr4-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03929.x"},{"key":"bibr5-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201810-1944CI"},{"key":"bibr6-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"bibr7-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90931-8"},{"key":"bibr8-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.07.010"},{"key":"bibr9-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0667"},{"key":"bibr10-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0059-1"},{"issue":"28","key":"bibr11-19458924221080260","first-page":"1","volume":"57","author":"Rimmer J","year":"2019","journal-title":"Rhinology"},{"key":"bibr12-19458924221080260","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010200"},{"issue":"29","key":"bibr13-19458924221080260","first-page":"1","volume":"58","author":"Fokkens WJ","year":"2020","journal-title":"Rhinology"},{"key":"bibr14-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.02.018"},{"key":"bibr15-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"bibr16-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22025"},{"key":"bibr17-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2618"},{"key":"bibr18-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1177\/1945892418801389"},{"key":"bibr19-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2007.11.002"},{"key":"bibr20-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.02.018"},{"key":"bibr21-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22287"},{"key":"bibr22-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24305"},{"key":"bibr23-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.11.038"},{"key":"bibr24-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811403077"},{"key":"bibr25-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.06.037"},{"key":"bibr26-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.022"},{"key":"bibr27-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.05.026"},{"key":"bibr28-19458924221080260","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S275068"},{"key":"bibr29-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22190"},{"key":"bibr30-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22499"},{"key":"bibr31-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1554"},{"key":"bibr32-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22462"},{"issue":"2","key":"bibr33-19458924221080260","first-page":"109","volume":"43","author":"Moncada S","year":"1991","journal-title":"Pharmacol Rev"},{"key":"bibr34-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)80083-2"},{"key":"bibr35-19458924221080260","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1324"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19458924221080260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19458924221080260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19458924221080260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:37:11Z","timestamp":1777369031000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19458924221080260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/19458924221080260"],"URL":"https:\/\/doi.org\/10.1177\/19458924221080260","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,3]]}}}