{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:41:19Z","timestamp":1791301279584,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temperature-controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN; RhinAer) is a minimally invasive treatment option for patients with chronic rhinitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine clinical outcomes and quality of life (QoL) following TCRF neurolysis of the PNN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective single-arm study of 129 patients with chronic rhinitis at 16 medical centers in the United States and Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean 24-h reflective total nasal symptom score (rTNSS) improved from 7.8 (95% CI, 7.5-8.1) at baseline to 3.6 (95% CI, 3.2-4.0) at 3 months and continued to improve to 2.9 (95% CI, 2.5-3.3) at 6 months ( p\u2009&lt;\u2009.001 comparing follow-up to baseline and p\u2009=\u2009.002 comparing 3 and 6 months). This represents 53.8% improvement over baseline at 3 months and 62.8% improvement at 6 months. Rhinorrhea, congestion, sneezing, and itching subscores and postnasal drip and cough scores were all significantly improved over baseline at both timepoints. At 3 months, 76.2% (95% CI, 68.1%-82.8%) of patients achieved a minimal clinically important difference of \u226530% improvement in rTNSS over baseline and the percentage was higher at 6 months (83.5% [95% CI, 75.8%-89.0%]). At 3 months, 80.3% (95% CI, 72.6%-86.3%) reported a minimal clinically important difference of \u22650.4-point improvement in the mini rhinoconjunctivitis quality of life questionnaire score, and the percentage was higher at 6 months; 87.7% (95% CI, 80.7%-92.4%). There were no serious adverse events with a relationship to the device\/procedure reported through 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large, multicenter study, TCRF neurolysis of the PNN was safe and resulted in a significant reduction in rhinitis symptom burden at 3 months that was sustained\/improved through 6 months. The majority of patients reported a clinically relevant improvement in QoL at 3 and 6 months postprocedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924221109987","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T02:51:05Z","timestamp":1657594265000},"page":"747-754","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Clinical and Quality of Life Outcomes Following Temperature-Controlled Radiofrequency Neurolysis of the Posterior Nasal Nerve (RhinAer) for Treatment of Chronic Rhinitis"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-855X","authenticated-orcid":false,"given":"Jivianne T.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Advanced ENT and Allergy, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Charous","sequence":"additional","affiliation":[{"name":"Arizona Desert Ear, Nose & Throat Specialists, Goodyear, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PD Dr. med. Mandy","family":"Cuevas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Clinic Carl Gustav Carus, Technical University of Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prof. Dr. med. \u00d6nder","family":"G\u00f6ktas","sequence":"additional","affiliation":[{"name":"ENT-Center, HNO-Zentrum am Kudamm, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Loftus","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan E.","family":"Nachlas","sequence":"additional","affiliation":[{"name":"ENT and Allergy Associates of Florida, Boca Raton, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina M.","family":"Toskala","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Fort Worth ENT Group, Fort Worth, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prof. Dr. med. Detlef","family":"Brehmer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Witten\/Herdecke, Witten, Germany"},{"name":"Department of Electrical Engineering and Applied Natural Sciences, Westphalian University of Applied Sciences, Gelsenkirchen, Germany"},{"name":"Department of Otorhinolaryngology, Private ENT Practice, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"bibr1-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22073"},{"key":"bibr2-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.09.002"},{"key":"bibr3-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116008008"},{"key":"bibr4-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1016\/j.otot.2007.05.010"},{"key":"bibr5-19458924221109987","first-page":"1907862","author":"Takahara D","year":"2017","journal-title":"Int J Otolaryngol"},{"key":"bibr6-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X211041124"},{"key":"bibr7-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211033400"},{"key":"bibr8-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21991"},{"key":"bibr9-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28301"},{"key":"bibr10-19458924221109987","author":"Ow RA","journal-title":"Laryngoscope"},{"key":"bibr11-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22868"},{"key":"bibr12-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102396"},{"key":"bibr13-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2003.00420.x"},{"key":"bibr14-19458924221109987","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00668.x"},{"key":"bibr15-19458924221109987","unstructured":"Glacy J, Putnam K, Godfrey S, et al. 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