{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:26:30Z","timestamp":1785464790069,"version":"3.56.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis (CRS) and eosinophilic esophagitis (EoE) are immune-mediated inflammatory conditions that share common histopathologic features. Once considered two separate pathologies, preliminary data has suggested that a higher prevalence of EoE may exist in patients with CRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to expand the base of evidence across geographic regions and investigate the association between EoE and CRS, including CRS with nasal polyposis (CRSwNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Quantitative data detailing the prevalence of CRS, CRSwNP, and EoE were pooled from 6 large academic institutions spread across the United States using Epic electronic medical record system. One-way analysis of variance was then used to analyze the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean prevalence of EoE in our general population sample of over 26 million individual records was 0.058% (range, 0.013%-0.103%). The mean prevalence of EoE in our sub-populations of individual with diagnoses of CRS and CRSwNP was 0.43% (F(1,12)\u2009\u2009=\u2009\u2009[8.194], P\u2009\u2009=\u2009\u2009.01) and 0.84% (F(1,12)\u2009\u2009=\u2009\u2009[23.61], P\u2009&lt;\u2009.01) respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reveals an 8-fold greater prevalence of concurrent EoE in patients with CRS. Importantly, this is the first study to describe the association of EoE and the CRSwNP subtype, and we demonstrate a 14-fold greater prevalence of EoE in patients with CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924221116162","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T21:27:32Z","timestamp":1663018052000},"page":"804-807","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6873-7760","authenticated-orcid":false,"given":"Jordan K.","family":"Simmons","sequence":"first","affiliation":[{"name":"Snot Force Alliance"},{"name":"Division of Otolaryngology, Cedars-Sinai Medical Center, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Leiman","sequence":"additional","affiliation":[{"name":"Snot Force Alliance"},{"name":"Division of Gastroenterology, Duke University School of Medicine, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita U.","family":"Patil","sequence":"additional","affiliation":[{"name":"Snot Force Alliance"},{"name":"Division of Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"McCoul","sequence":"additional","affiliation":[{"name":"Snot Force Alliance"},{"name":"Department of Otorhinolaryngology, Ochsner Clinic Foundation, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-3324","authenticated-orcid":false,"given":"Philip G.","family":"Chen","sequence":"additional","affiliation":[{"name":"Snot Force Alliance"},{"name":"Department of Otolaryngology, University of Texas Health at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis M.","family":"Tang","sequence":"additional","affiliation":[{"name":"Snot Force Alliance"},{"name":"Division of Otolaryngology, Cedars-Sinai Medical Center, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-0718","authenticated-orcid":false,"given":"Edward C.","family":"Kuan","sequence":"additional","affiliation":[{"name":"Snot Force Alliance"},{"name":"Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena E.","family":"Chang","sequence":"additional","affiliation":[{"name":"Snot Force Alliance"},{"name":"Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-6355","authenticated-orcid":false,"given":"Arthur W.","family":"Wu","sequence":"additional","affiliation":[{"name":"Snot Force Alliance"},{"name":"Division of Otolaryngology, Cedars-Sinai Medical Center, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"bibr1-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00538-7"},{"key":"bibr2-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.04.024"},{"key":"bibr3-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.5MR0120-230R"},{"key":"bibr4-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.4177"},{"key":"bibr5-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.4"},{"key":"bibr6-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.065"},{"key":"bibr7-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"},{"key":"bibr8-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.067"},{"key":"bibr9-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.004"},{"key":"bibr10-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25798"},{"key":"bibr11-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511401103"},{"key":"bibr12-19458924221116162","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12141"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19458924221116162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19458924221116162","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19458924221116162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:37:28Z","timestamp":1777369048000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/19458924221116162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1177\/19458924221116162"],"URL":"https:\/\/doi.org\/10.1177\/19458924221116162","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,12]]}}}