{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:39:19Z","timestamp":1793014759876,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the science and technology research project of Education Department of Jiangxi Province","award":["No. GJJ161455"],"award-info":[{"award-number":["No. GJJ161455"]}]},{"name":"the science and technology research project of Education Department of Jiangxi Province","award":["No.200116"],"award-info":[{"award-number":["No.200116"]}]},{"name":"Natural Science Foundation of Jiangxi science and Technology Department","award":["20202BAB206036"],"award-info":[{"award-number":["20202BAB206036"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["816601170"],"award-info":[{"award-number":["816601170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860183"],"award-info":[{"award-number":["81860183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and technology plan of Jiangxi Health Committee","award":["20165120"],"award-info":[{"award-number":["20165120"]}]},{"name":"Science and technology plan of Jiangxi Health Committee","award":["20203226"],"award-info":[{"award-number":["20203226"]}]},{"name":"Science and technology plan of Jiangxi Health Committee","award":["202131020"],"award-info":[{"award-number":["202131020"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypersecretion of mucin 5AC (MUC5AC) is a prominent feature of chronic rhinosinusitis with nasal polyps (CRSwNP) and autophagy plays a pivotal role in this process. TNF receptor-associated factor 6 (TRAF6) functions as a signal transducer in many inflammation diseases, whereas the correlation between TRAF6 and autophagy in CRSwNP remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the role of TRAF6 in the human neutrophil elastase (HNE)-induced autophagy and mucin MUC5AC over-expression in CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Tissue specimens were obtained from control subjects and patients with CRSwNP. The relationships between HNE, TRAF6, autophagy, and MUC5AC were investigated. The effect of TRAF6 on HNE-mediated autophagy and hypersecretion of MUC5AC was assessed by in-vitro culture of HNECs treated with human recombinant HNE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with CRSwNP had more protein expression of HNE, MUC5AC, TRAF6, and light chain (LC3B), and increased levels of Beclin-1(BECN1) and autophagy-related gene 5 (ATG5) in mRNA level. Treatment of nasal epithelial cells with recombinant HNE induced the upregulation of TRAF6, autophagy, and MUC5AC. Alternatively, si-TRAF6 or autophagy inhibitor treatment mitigates the hyperexpression of MUC5AC before incubating with recombinant HNE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HNE promotes autophagy through TRAF6, resulting in hyperexpression of MUC5AC in CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924221116939","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T03:05:12Z","timestamp":1659409512000},"page":"816-826","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["HNE Induces the Hyperexpression of MUC5AC in Chronic Rhinosinusitis With Nasal Polyps by Activating the TRAF6\/Autophagy Regulatory Axis"],"prefix":"10.1177","volume":"36","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangquan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-0106","authenticated-orcid":false,"given":"Qing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"bibr1-19458924221116939","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-052016-100401"},{"key":"bibr2-19458924221116939","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4252"},{"key":"bibr3-19458924221116939","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-00958-w"},{"key":"bibr4-19458924221116939","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2016.1144145"},{"key":"bibr5-19458924221116939","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2037-0"},{"key":"bibr6-19458924221116939","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.334375"},{"key":"bibr7-19458924221116939","doi-asserted-by":"crossref","unstructured":"Park J-A, He F, Martin LD, et al. 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