{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:35:29Z","timestamp":1777386929609,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The pathogenesis of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) remains still inconclusive. Recent studies identified an increased expression of BAFF (a B cell-activating factor) and its receptor TACI (Transmembrane Activator and cAML Interactor) in nasal polyp samples, while TNFRSF13B\/TACI mutations have been found in patients with benign lymphoproliferative disorders and primary antibody deficiencies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of our study was to evaluate the possible contribution of TNFRSF13B\/TACI mutations in CRSwNP pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-four (44) patients with CRSwNP (male\/female: 33\/11, mean age: 52.5 years, range: 16-83) were analyzed for TNFRSF13B\/TACI mutations by PCR-sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No pathogenic TNFRSF13B\/TACI mutations were identified in our cohort study of CRSwNP patients. We detected two common missense mutations (p.P251L and p.V220A), along with other common silent mutations and intronic polymorphisms in an identical prevalence to healthy control population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TNFRSF13B\/TACI mutations might not play a role in the pathogenesis of CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924221134731","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T02:35:45Z","timestamp":1666924545000},"page":"74-77","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>TNFRSF13B\/TACI<\/i>\n                    Mutations in Patients with Chronic Rhinosinusitis with Nasal Polyps"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1925-4249","authenticated-orcid":false,"given":"Georgia K.","family":"Tsiouma","sequence":"first","affiliation":[{"name":"Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Thessaly, Greece"},{"name":"ENT Department, General Hospital of Volos, Volos, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampos E.","family":"Skoulakis","sequence":"additional","affiliation":[{"name":"ENT Department, University Hospital of Larissa, Larissa, Thessaly, Greece"},{"name":"Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios A.","family":"Lachanas","sequence":"additional","affiliation":[{"name":"ENT Department, University Hospital of Larissa, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini G.","family":"Sevdali","sequence":"additional","affiliation":[{"name":"Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7162-4377","authenticated-orcid":false,"given":"Gerasimina N.","family":"Tsinti","sequence":"additional","affiliation":[{"name":"Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoi A.","family":"Florou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efthymia A.","family":"Petinaki","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthaios G.","family":"Speletas","sequence":"additional","affiliation":[{"name":"Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"bibr1-19458924221134731","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"bibr2-19458924221134731","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S2379"},{"key":"bibr3-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21780"},{"key":"bibr4-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01964.x"},{"key":"bibr5-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.03.002"},{"key":"bibr6-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/478753"},{"key":"bibr7-19458924221134731","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.807"},{"key":"bibr8-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1038\/79802"},{"key":"bibr9-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/247426"},{"key":"bibr10-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1038\/ng1601"},{"key":"bibr11-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1038\/ng1600"},{"key":"bibr12-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.001"},{"key":"bibr13-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-015958"},{"key":"bibr14-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/532437"},{"key":"bibr15-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00460-10"},{"key":"bibr16-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9536-4"},{"key":"bibr17-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31023"},{"key":"bibr18-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-141937"},{"key":"bibr19-19458924221134731","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200102000-00008"}],"container-title":["American 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