{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:12:16Z","timestamp":1783440736636,"version":"3.54.6"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease with no known single cause, but it is thought that bacteria play a role in the disease process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This pilot study aims to assess the longitudinal effect of corticosteroid therapy on sinus microbiota in chronic rhinosinusitis patients with nasal polyposis (CRSwNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A longitudinal prospective case-control study was done on patients with CRSwNP and healthy controls. Patients with CRSwNP were randomly allocated to a corticosteroids and antibiotics treatment group (CRSwNP-SA) or a corticosteroid-only treatment group (CRSwNP-S). Data were collected at three-time points (before treatment, 1, and 3 months after treatment). Specimens were cultured and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS) was used as a bacterial detection method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 29 patients with CRSwNP (16 CRSwNP-SA and 13 CRSwNP-S) was compared to 15 healthy subjects. Patients reported significant symptom improvement initially (1 month), but not in the long-term (3 months). This result was found in both treatment groups, whether or not antibiotics were used. After 3 months from treatment, the prevalence of Corynebacterium genera tended to increase in the CRSwNP-SA, while Staphylococcus and Gram-negative genera (Pseudomonas) tended to increase in the CRSwNP-S. Smoking, aspirin sensitivity, and previous endoscopic sinus surgery were found to be co-factors significantly associated with the response to systemic corticosteroid therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this pilot study, both treatment options were effective to improve symptoms in the short-term but not in the long-term, and were not linked to any clear sinus microbiota response. As a result, this study supports the avoidance of systemic antibiotics without evidence of active infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924231183848","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T01:07:29Z","timestamp":1689901649000},"page":"638-645","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Effect of Corticosteroids on Sinus Microbiota in Chronic Rhinosinusitis Patients with Nasal Polyposis"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2791-4550","authenticated-orcid":false,"given":"Yousif","family":"Alammar","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, McGill University, Montreal, Canada"},{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Rousseau","sequence":"additional","affiliation":[{"name":"The Meakins-Christie Laboratories, Research Institute at McGill University Health Centre, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, University of Montreal, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Tewfik","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"bibr1-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-7-2"},{"issue":"205","key":"bibr2-19458924231183848","first-page":"1","volume":"10","author":"Blackwell DL","year":"2002","journal-title":"Vital Health Stat"},{"key":"bibr3-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"bibr4-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200307000-00016"},{"key":"bibr5-19458924231183848","unstructured":"IMS Health: Canadian Disease and Therapeutic Index (CDTI) database.2006."},{"key":"bibr6-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815574247"},{"key":"bibr7-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.049"},{"key":"bibr8-19458924231183848","first-page":"1","volume":"20","author":"Hamilos DL","year":"2007","journal-title":"Clin Allergy Immunol"},{"key":"bibr9-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0540-2"},{"key":"bibr10-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22398"},{"key":"bibr11-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21871"},{"key":"bibr12-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22110"},{"key":"bibr13-19458924231183848","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00134"},{"issue":"29","key":"bibr14-19458924231183848","first-page":"1","volume":"58","author":"Fokkens WJ","year":"2020","journal-title":"Rhinology"},{"key":"bibr15-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21195"},{"key":"bibr16-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"bibr17-19458924231183848","first-page":"9","author":"Koeller K","year":"2018","journal-title":"Front Microbiol"},{"key":"bibr18-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.93"},{"key":"bibr19-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1111\/all.14276"},{"key":"bibr20-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13632"},{"key":"bibr21-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.03.001"},{"key":"bibr22-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000113"},{"key":"bibr23-19458924231183848","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3366"},{"key":"bibr24-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21805"},{"key":"bibr25-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085507"},{"key":"bibr26-19458924231183848","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21849"}],"container-title":["American Journal of Rhinology &amp; 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