{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:15:58Z","timestamp":1787019358739,"version":"build-2736575974"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This is the largest study in North America investigating olfactory outcomes after pituitary surgery to date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Characterize factors associated with subjective olfactory dysfunction (OD) and worsened sinonasal quality-of-life (QOL) after endoscopic TSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing primary TSA for secreting and non-secreting pituitary adenomas between 2017 and 2021 with pre- and post-operative SNOT-22 scores were included. Subjective OD was determined by the smell\/taste dysfunction question on the SNOT-22 (smell-SNOT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>159 patients with pre- and post-operative SNOT-22 scores were included. Average total SNOT-22 scores worsened from pre-operative (16.91\u2009\u00b1\u200916.91) to POM1 (25.15\u2009\u00b1\u200920.83, P\u2009&lt;\u2009.001), with no difference from pre-operative (16.40\u2009\u00b1\u200915.88) to POM6 (16.27\u2009\u00b1\u200917.92, P\u2009=\u2009.936) or pre-operative (13.63\u2009\u00b1\u200913.54) to POM12 (12.60\u2009\u00b1\u200916.45, P\u2009=\u2009.651). Average smell-SNOT scores worsened from pre-operative (0.40\u2009\u00b1\u20091.27) to POM1 (2.09\u2009\u00b1\u20092.01, P\u2009&lt;\u2009.001), and pre-operative (0.46\u2009\u00b1\u20091.29) to POM6 (1.13\u2009\u00b1\u20092.45, P\u2009=\u2009.002), with no difference from pre-operative (0.40\u2009\u00b1\u20091.07) to POM12 (0.71\u2009\u00b1\u20091.32, P\u2009=\u2009.100). Female gender had a 0.9-point (95% CI 0.1 to 1.6) P\u2009=\u2009.021, increase in smell-SNOT at POM1, resolving by POM6 (0.1 [\u22120.9 to 1.1], P\u2009=\u2009.800) and POM12 (0.0 [\u22121.0 to 0.9], P\u2009=\u2009.942). Septoplasty with tunnel approach had a 1.1 [0.2 to 2.0] out of 5-point ( P\u2009=\u2009.023) increase in smell-SNOT at POM1, resolving by POM6 (0.2 [\u22121.1 to 1.6], P\u2009=\u2009.764) and POM12 (0.4 [\u22120.9 to 1.6], P\u2009=\u2009.567). Female gender had a 9.5 (4.0 to 15.1)-point ( P\u2009=\u2009.001) increase in SNOT-22 scores at POM1, resolving by POM6 (3.4 [\u22123.0 to 9.8], P\u2009=\u2009.292) and POM12 (6.4 [\u22125.4 to 18.2], P\u2009=\u2009.276). Intra-operative CSF leak had an 8.6 [2.1 to 15.1]-point ( P\u2009=\u2009.009) increase in SNOT-22 scores at POM1, resolving by POM6 (5.4 [\u22121.7 to 12.5], P\u2009=\u2009.135), and POM12 (1.1 [\u221212.9 to 15.1], P\u2009=\u2009.873).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Changes in subjective olfaction and sinonasal QOL after TSA may be associated with gender, operative approach, and intra-operative CSF leak, resolving 6-12 months post-operatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924241243123","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T04:26:55Z","timestamp":1713760015000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Predictors of Subjective Olfactory Dysfunction and Sinonasal Quality-of-Life After Endoscopic Transsphenoidal Pituitary Surgery"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7679-0908","authenticated-orcid":false,"given":"Bita R.","family":"Naimi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Farquhar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6847-442X","authenticated-orcid":false,"given":"Alexander N.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily 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