{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:00:25Z","timestamp":1788436825299,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study aims to compare Chitogel\n                      <jats:sup>\u00ae<\/jats:sup>\n                      with topical corticosteroid versus PureRegen\n                      <jats:sup>\u00ae<\/jats:sup>\n                      gel on wound healing and postoperative outcomes in the treatment of chronic rhinosinusitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A double-blinded randomized controlled trial was performed with patients undergoing functional endoscopic sinus surgery who were prospectively recruited and randomized to receive Chitogel with triamcinolone to one side of the sinuses and PureRegen to the contralateral sinuses. The patients underwent endoscopic follow-up at 2, 6, and 12 weeks postoperatively. Patient factors including age, gender, smoking status, comorbidities (reflux, allergy, and asthma), and disease specific factor (chronic rhinosinusitis phenotype) were collected. Sinus ostial measurements, adhesions, mucopurulent discharge, edema, crusting, and granulation were assessed. A visual analogue scale questionnaire on quality of life was assessed in each follow-up appointment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 40 patients were randomized. At 12 weeks, Chitogel had a 10.7\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      reduction in frontal sinus ostium area compared to 15\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      in the PureRegen group; Chitogel had a 2.2\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      increase in maxillary ostium area compared to 0.1\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      in the PureRegen group; Chitogel had a 27.6\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      reduction in area of the sinus ostium compared to 28.7\u2005mm\n                      <jats:sup>2<\/jats:sup>\n                      in the PureRegen group. However, these differences were not statistically significant. The difference between the two groups when analysing adhesion, mucopurulent discharge, mucosal oedema, crusting, granulation, and phenotype was not statistically significant. Patient self-directed grading on quality of life was not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both Chitogel with triamcinolone and PureRegen have demonstrated to be great options to prevent adhesion, stenosis, and optimize healing. There were no clinical and statistical differences between both products in wound healing and postoperative outcomes in the treatment of chronic rhinosinusitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924251321142","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T09:07:32Z","timestamp":1742375252000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Double-Blinded Randomised Controlled Trial Evaluating the Efficacy of Chitogel Versus PureRegen Gel on Postoperative Outcomes from Endoscopic Sinus Surgery"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-8942","authenticated-orcid":false,"given":"Marina N.","family":"Cavada","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Sydney Adventist Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-0404","authenticated-orcid":false,"given":"Michael Fook-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Hornsby Ku-ring-gai Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjuna","family":"Ananda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Concord General Hospital, University of Sydney, Sydney, Australia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Campbelltown Private Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Sacks","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Sydney Adventist Hospital, Sydney, Australia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Concord General Hospital, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuresh S.","family":"Naidoo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Sydney Adventist Hospital, Sydney, Australia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Concord General Hospital, University of Sydney, Sydney, Australia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Campbelltown Private Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"issue":"29","key":"e_1_3_2_2_2","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens WJ","year":"2020","unstructured":"Fokkens WJ, Lund VJ, Hopkins C, et al. 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