{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:28:35Z","timestamp":1777386515247,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol&amp;#65533;Allergy"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Olfactory dysfunction (OD) is both under-recognized and underdiagnosed in aging adults. Prior studies in chronic rhinosinusitis have demonstrated a correlation between the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS) and psychophysical olfactory testing, indicating potential utility for screening in this group. This study examined the correlation between QOD-NS scores, psychophysical function, and olfactory-associated patient-reported outcome measures (PROMs) in a novel, aging population. Additionally, we examined the potential utility of the QOD-NS as a screening instrument in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective cohort study in which healthy, adult volunteers completed the QOD-NS, olfaction-related visual analog scale (VAS) questions, Sniffin\u2019 Sticks (TDI), De Jong Giervald Loneliness Scale, UCLA loneliness survey (UCLA), and the Patient Health Questionnaire-9 (PHQ9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two-hundred and twenty-eight adults with mean age 50.3\u2009\u00b1\u200917.7 years were included. Subjects \u226550 years old had higher prevalences of hyposmia (58.3% vs 19.8%, P\u2009&lt;\u20090.001) and anosmia (9.1% vs 3.1%, P\u2009&lt;\u20090.001), and had worse QOD-NS and VAS (P\u2009&lt;\u20090.001 for both). Aging subjects had significant correlations between QOD-NS and TDI (r\u2009=\u2009\u20130.386, p\u2009&lt;\u20090.001), all VAS scores (P\u2009&lt;\u20090.001), PHQ9 (r\u2009=\u20090.283, P\u2009=\u20090.001). Receiver operating characteristic curve demonstrated a QOD-NS of 8.0 as the optimal cutoff for a Youden's index of 0.23 for detection of dysosmia in aging patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The QOD-NS has significant, although weak correlation with psychophysical testing and psychosocial PROMs in aging subjects. However, a low Youden Index suggests limited potential of the QOD-NS as an OD screening tool in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924251382100","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:00:27Z","timestamp":1761580827000},"page":"105-111","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Utility of the Questionnaire of Olfactory Disorders-Negative Statements in Age-Related Olfactory Dysfunction"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6847-442X","authenticated-orcid":false,"given":"Alexander","family":"Duffy","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Medical University of South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4304-595X","authenticated-orcid":false,"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Medical University of South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina A.","family":"LaPointe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Medical University of South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6480-0275","authenticated-orcid":false,"given":"Rod J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Medical University of South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"issue":"1","key":"e_1_3_2_2_2","first-page":"20","article-title":"The influences of age on olfaction: A review","volume":"5","author":"Doty RL","year":"2014","unstructured":"Doty RL, Kamath V. The influences of age on olfaction: A review. 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