{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:41:30Z","timestamp":1790628090253,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Henan Provincial Medical Science and Technology Research Project","award":["No: SBGJ202302064"],"award-info":[{"award-number":["No: SBGJ202302064"]}]},{"name":"the Young and middle-aged Health Science and Technology Innovation Talent Project of Henan Province","award":["No: LJRC2023009"],"award-info":[{"award-number":["No: LJRC2023009"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2026,5]]},"abstract":"\n Background<\/jats:title>\n At present, there are many therapeutic regimens for allergic rhinitis (AR), but their therapeutic effects are not better. Therefore, it is a focus to find new therapeutic targets by exploring AR immune regulation.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To explore the possible mechanism that adipose mesenchymal stem cell-derived exosomes (AMSC-exos) regulate the balance of Th2\/Treg cells by mTOR pathway in AR patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Thirty patients with AR and 30 patients with deviated nasal septum alone were selected as AR group and control group. From each patient, 10\u2005ml of peripheral blood were collected for determining the levels of blood plasma IL-4 and TGF- \u03b2 as well as protein levels of p-PI3K (P85), p-AKT (Ser473), p-mTOR (Ser2448) and p-p70S6K (Thr389) in peripheral blood mononuclear cells (MCs) and the proportions of Th2 and Treg cells. And then MCs from AR patients were divided into two groups. One group was as AR cell group. Another group was co-cultured with AMSC-exos and served as AR cell\u2009+\u2009exos group. The levels of IL-4 and TGF- \u03b2 in supernatant, the protein levels of p-PI3K (P85), p-AKT (Ser473), p-mTOR (Ser2448) and p-p70S6K (Thr389) in MCs and the proportions of Th2 and Treg cells were also determined.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The levels of p-PI3K (P85), p-AKT (Ser473), p-mTOR (Ser2448) and p-p70S6K (Thr389), the IL-4 level and the proportion of Th2 cells were significantly higher in the AR group than in the control group (all\n P<\/jats:italic>\n \u2009<\u20090.05). However, the levels of p-PI3K (P85), p-AKT (Ser473), p-mTOR (Ser2448) and p-p70S6K (Thr389), the IL-4 level and the proportion of Th2 cells were significantly lower in the AR cell\u2009+\u2009exos group than in the AR cell group (all\n P<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n AMSC-exos may regulate the balance between Th2 and Treg cells by PI3K\/AKT\/mTOR\/p70S6K pathways in vitro.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/19458924251401732","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T15:01:18Z","timestamp":1764774078000},"page":"183-190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Adipose Mesenchymal Stem Cell-Derived Exosomes on the Th2\/Treg Cells in Peripheral Blood of the Patients with Allergic Rhinitis and its Mechanism"],"prefix":"10.1177","volume":"40","author":[{"given":"Feiyan","family":"Han","sequence":"first","affiliation":[{"name":"the Fifth Affiliated Hospital of Zhengzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Xu","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Zhengzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1699-6905","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Zhengzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.02.025"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.09.004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0110044"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.08.026"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.09.194"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27201"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.08.127"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0896-z"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0283"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.12.021"},{"key":"e_1_3_2_12_2","first-page":"92","article-title":"Research progress of exosome in the pathogenesis of allergic rhinitis","volume":"46","author":"Zhiyu P","year":"2022","unstructured":"Zhiyu P, Shaoqin Y. Research progress of exosome in the pathogenesis of allergic rhinitis. Guo Ji Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022;46:92-95.","journal-title":"Guo Ji Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep32993"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0417-0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2014.6.2.105"},{"key":"e_1_3_2_16_2","first-page":"457","article-title":"Progress in the risk factors for allergic rhinitis combined with airway hyperresponsiveness","volume":"37","author":"Jinjin Z","year":"2023","unstructured":"Jinjin Z, Yanwen C, Yadong G. Progress in the risk factors for allergic rhinitis combined with airway hyperresponsiveness. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023;37:457-462.","journal-title":"Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3244"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5590217"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01526.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010239"},{"key":"e_1_3_2_21_2","first-page":"209","article-title":"Research progress of exosomes in allergic rhinitis","volume":"36","author":"Fang Z","year":"2023","unstructured":"Fang Z, Hai L, Jianhui Z. Research progress of exosomes in allergic rhinitis. Yi Xue Yan Jiu Yu Zhan Chuang Shang Jiu Zhi. 2023;36:209-213.","journal-title":"Yi Xue Yan Jiu Yu Zhan Chuang Shang Jiu Zhi"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.09.012"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2012.08.008"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.016"},{"issue":"2","key":"e_1_3_2_25_2","first-page":"1","article-title":"mTOR: From growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu R","year":"2011","unstructured":"Zoncu R, Efeyan A, Sabatini DM. mTOR: From growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011;12(2):1-35.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102278"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04826-y"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020548"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S527137"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v17.i4.102917"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2023-101143"},{"key":"e_1_3_2_32_2","first-page":"266","article-title":"Effects of exosomes from human adipose-derived mesenchymal stem cells on pulmonary vascular endothelial cells injury in septic mice and its mechanism","volume":"38","author":"Cai W X","year":"2022","unstructured":"Cai W X, Shen K, Cao T, et al. Effects of exosomes from human adipose-derived mesenchymal stem cells on pulmonary vascular endothelial cells injury in septic mice and its mechanism. Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022;38:266-275.","journal-title":"Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi"}],"container-title":["American Journal of Rhinology & Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19458924251401732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19458924251401732","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19458924251401732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:36:27Z","timestamp":1777368987000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19458924251401732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/19458924251401732"],"URL":"https:\/\/doi.org\/10.1177\/19458924251401732","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]}}}