{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:56:20Z","timestamp":1781132180277,"version":"3.54.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2023-NHLHCRF-PY-01"],"award-info":[{"award-number":["2023-NHLHCRF-PY-01"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504105"],"award-info":[{"award-number":["2022YFC2504105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol&amp;#65533;Allergy"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate and compare the efficacy and safety of endoscopic neurectomy versus radiofrequency ablation targeting both the posterior nasal nerve (PNN) and lateral internal nasal branches of the anterior ethmoidal nerve (LINB-AEN) in patients with allergic rhinitis (AR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective randomized controlled trial, adult patients with moderate to severe AR undergoing endoscopic nerve intervention from November 2023 to September 2025 were randomized to receive either neurectomy or ablation. Surgical targets included both PNN and LINB-AEN. Outcomes were assessed at 1, 3, and 6 months postoperatively and included nasal symptom visual analog scale (VAS), total nasal symptom score (TNSS), rhinoconjunctivitis quality of life questionnaire (RQLQ), total nasal resistance (TNR), olfactory function (VAS, QOD-NS, and Sniffin\u2019 Sticks), and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      61 patients completed follow-up (neurectomy group: n\u2009=\u200930; ablation group: n\u2009=\u200931). Both groups achieved significant symptomatic improvement by 6 months (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The ablation group demonstrated significantly greater improvement in nasal obstruction (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and sneezing (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008) at 1 month, while the neurectomy group showed earlier improvement in rhinorrhea (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002). Both procedures improved nasal resistance. Neurectomy provided a faster, sustained nasal resistance improvement (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      <jats:sub>3 months<\/jats:sub>\n                      \u2009=\u20090.001,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      <jats:sub>6 months<\/jats:sub>\n                      \u2009=\u20090.003) with superior improvement in odor identification (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and TDI score (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.005). Notably, no serious complications were reported. Additionally, symptoms of nasal dryness improved from baseline in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first randomized controlled study to compare dual-target endoscopic neurectomy and ablation for AR. Both approaches are effective and safe. Ablation offers faster symptom relief, while neurectomy provides superior long-term control of nasal airflow and olfactory function. Individualized surgical planning is recommended based on symptom profile and patient preference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry Identifier: ChiCTR2500111543<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924261429542","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:19:40Z","timestamp":1773825580000},"page":"345-354","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Neurectomy Versus Ablation of Posterior Nasal and Anterior Ethmoidal Nerve for Allergic Rhinitis: A Prospective Randomized Comparative Study"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4598-6490","authenticated-orcid":false,"given":"Shanshan","family":"Zhang","sequence":"first","affiliation":[{"name":"Graduate School of Beijing University of Chinese Medicine"},{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9300-6919","authenticated-orcid":false,"given":"Yihan","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate School of Beijing University of Chinese Medicine"},{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7543-4456","authenticated-orcid":false,"given":"Jianhui","family":"Zhao","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5427-2580","authenticated-orcid":false,"given":"Jun","family":"Han","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-9360","authenticated-orcid":false,"given":"Yibei","family":"Wang","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiding","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4071-6719","authenticated-orcid":false,"given":"Jianfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate School of Beijing University of Chinese Medicine"},{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"issue":"1","key":"e_1_3_3_2_2","article-title":"Clinical practice guideline: Allergic rhinitis","volume":"152","author":"Seidman MD","year":"2015","unstructured":"Seidman MD, Gurgel RK, Lin SY, et al. 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