{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:11:15Z","timestamp":1786374675677,"version":"build-2736575974"},"reference-count":37,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Taiwan National Science and Technology Council","award":["114-2314-B-182 -031 -MY2"],"award-info":[{"award-number":["114-2314-B-182 -031 -MY2"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endotype identification based on clinical characteristics is crucial for the selection and prediction of the efficacy of various therapeutic modalities in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the clinical characteristics of patients with non-type 2 (non-T2) CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and laboratory data, as well as nasal tissues, were collected from adult patients who underwent endoscopic sinus surgery (ESS) for primary diffuse CRSwNP. Non-T2 CRSwNP was defined as a tissue eosinophil count &lt;10\/high power field. The levels of interleukin (IL)-5 and IL-13 in nasal polyps were measured using real-time polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 199 patients with bilateral CRSwNP were recruited. Sixty-five (32.7%) exhibited non-T2 CRSwNP. Regression analysis revealed that male sex, absence of asthma, low ethmoid\/maxillary (E\/M) ratio, high blood neutrophil, low lymphocyte, and low eosinophil percentages were significantly associated with non-T2 inflammation in patients with CRSwNP. Age and nasal polyp score were significant predictors of postoperative residual sinus inflammation\u2014defined as a modified Lund-Kennedy endoscopy score of \u22655 at 3 months after surgery\u2014in patients with non-T2 CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Male sex, absence of asthma, E\/M ratio, and the percentages of neutrophils, lymphocytes, and eosinophils were significantly associated with non-T2 CRSwNP. Age and polyp score were predictors of postoperative residual sinus inflammation in patients with non-T2 CRSwNP. These findings may help clinicians better evaluate patients with non-T2 CRSwNP and provide optimal therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924261436871","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:45:58Z","timestamp":1775486758000},"page":"384-393","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Characteristics of Patients with Non-Type 2 Chronic Rhinosinusitis with Nasal Polyps"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7549-9633","authenticated-orcid":false,"given":"Pei-Wen","family":"Wu","sequence":"first","affiliation":[{"name":"Chang Gung Memorial Hospital and Chang Gung University"},{"name":"School of Medicine, Chang Gung University, Taoyuan, Taiwan"},{"name":"Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, 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