{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:30:27Z","timestamp":1787596227643,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol&amp;#65533;Allergy"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease with variable response to biologic therapy. Tissue-based predictors of treatment response are limited, and conventional eosinophil-focused histopathology has shown inconsistent predictive value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess whether artificial intelligence (AI)-derived baseline histopathology of nasal polyps contains information associated with clinical response to mepolizumab in CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This hypothesis-generating substudy included patients with severe CRSwNP enrolled in a randomized controlled trial. Baseline biopsies were analysed using an AI-driven spatial histopathology pipeline extracting 84 morphological features per cell. Features were evaluated in eosinophil-only, noneosinophil, and all-cell configurations. Treatment response at 6 and 12 months was defined using EUFOREA criteria. Linear discriminant analysis and partial least squares regression were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty-eight patients were included. At 12 months, the eosinophil-only model showed limited discrimination (AUC \u2248 0.43), the noneosinophil model moderate discrimination (AUC \u2248 0.62), and the all-cell model the highest performance (AUC \u2248 0.75). At 6 months, all models showed limited discrimination (AUC \u2248 0.49). For continuous outcomes, noneosinophil models explained the greatest variance (R\n                      <jats:sup>2<\/jats:sup>\n                      up to \u2248 0.34).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AI-derived baseline histopathology contains information associated with clinical response to mepolizumab in CRSwNP. Models incorporating the broader tissue microenvironment outperformed eosinophil-focused approaches, supporting the potential of computational pathology for pretreatment stratification of biologic therapy in CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924261469379","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:59:36Z","timestamp":1787237976000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["AI-derived Histopathological Signatures Are Associated With Response to Mepolizumab in Chronic Rhinosinusitis With Nasal Polyps"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6924-1218","authenticated-orcid":false,"given":"Jens","family":"Tidemandsen","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1576-3679","authenticated-orcid":false,"given":"Simon","family":"H\u00f8j","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Hl","family":"Jensen","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stampe","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9716-6501","authenticated-orcid":false,"given":"Anne Sophie","family":"Hom\u00f8e","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2449-0924","authenticated-orcid":false,"given":"Marie","family":"H\u00f8xbro","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Aan\u00e6s","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0300-8311","authenticated-orcid":false,"given":"Sarah","family":"Charabi","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7806-7219","authenticated-orcid":false,"given":"Vibeke","family":"Backer","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.600"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.850494"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.08.009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.03.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.70010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.16499"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00097-7"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14111112"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-20-591"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000866"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.70073"},{"key":"e_1_3_3_13_2","unstructured":"Stampe Martin Christiansen Ida Skovgaard Backer Vibeke et al. 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