{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:56:38Z","timestamp":1785941798418,"version":"3.56.0"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001998"],"award-info":[{"award-number":["UL1TR001998"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol\ufffdAllergy"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The rate of functional endoscopic sinus surgery (FESS) in cystic fibrosis (CF) with chronic rhinosinusitis (CRS) is greater than 20%, and the rate of revision FESS is higher in CF patients compared to patients without CF. Revision FESS also occurs sooner in CF. Triple modulator therapy has made a positive impact on CRS symptoms and imaging in CF, but little is known regarding its relation to revision FESS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of CF patients with CRS treated at a single institution identified 53 patients who met inclusion criteria and underwent FESS between 2006 and 2022. There were 32 patients treated with triple modulator therapy, or elexacaftor\/tezacaftor\/ivacaftor (ETI). We hypothesized that ETI would be associated with a decreased likelihood of revision FESS. Additional cofactors included age, prior modulator treatment, and history of lung transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a decrease in revision FESS in patients treated with ETI, with only one of the 32 patients undergoing surgery since treatment initiation (3.13%). In the years prior to ETI, 18 of these same patients (56.25%) underwent revision FESS. Patients on other modulator therapy had a hazard ratio of 0.85 for revision FESS (not significant).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current study shows a low rate of revision FESS in patients taking ETI, consistent with prior reports on improved quality of life and radiographic measures in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924261470956","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:56:14Z","timestamp":1785765374000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Revision Endoscopic Sinus Surgery in Cystic Fibrosis With Chronic Rhinosinusitis: Before and After Cystic Fibrosis Transmembrane Conductance Regulator Triple Modulator Therapy"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3808-8936","authenticated-orcid":false,"given":"Brian P.","family":"Kinealy","sequence":"first","affiliation":[{"name":"University of Kentucky College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A.","family":"Mangino","sequence":"additional","affiliation":[{"name":"University of Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Kentucky College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasarae","family":"McKinney","sequence":"additional","affiliation":[{"name":"University of Kentucky College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Anstead","sequence":"additional","affiliation":[{"name":"University of Kentucky College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4155-5216","authenticated-orcid":false,"given":"Brett T.","family":"Comer","sequence":"additional","affiliation":[{"name":"University of Kentucky College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.02.009"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199309000-00008"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.162"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22716"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211046719"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202101-057OC"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.5334\/jbsr.2812"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.03.002"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2020.07.002"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.09.014"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22146"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.38038"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.08.009"}],"container-title":["American Journal of Rhinology &amp; Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19458924261470956","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19458924261470956","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19458924261470956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:19:20Z","timestamp":1785939560000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19458924261470956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":14,"alternative-id":["10.1177\/19458924261470956"],"URL":"https:\/\/doi.org\/10.1177\/19458924261470956","relation":{},"ISSN":["1945-8924","1945-8932"],"issn-type":[{"value":"1945-8924","type":"print"},{"value":"1945-8932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]},"article-number":"19458924261470956"}}