{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:10:35Z","timestamp":1793725835968,"version":"4.6.1"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Rhinol&amp;#65533;Allergy"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic otitis media (EOM) is a refractory type 2 inflammatory disease of the middle ear, frequently associated with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Conventional otologic treatments often provide incomplete or transient benefit. Because EOM and CRSwNP may share a type 2 inflammatory pathway involving the nasal, Eustachian tube, and middle-ear compartments, biologic therapy may offer benefit beyond sinonasal disease control. Long-term multicenter real-world data on dupilumab in patients with concomitant EOM and severe CRSwNP remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the 12-month effectiveness of dupilumab on subjective and objective otologic outcomes in adults with EOM and severe CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter observational cohort, 48 adults with severe CRSwNP and concomitant EOM, diagnosed according to Iino criteria, received dupilumab 300\u2005mg every 2 weeks. Otologic outcomes included the Chronic Otitis Media Outcome Test 15 (COMOT-15; range 0-75) and tympanometry. Sinonasal outcomes, including Nasal Polyp Score, SNOT-22, and visual analog scale of nasal congestion, were secondary measures. Outcomes were evaluated at baseline, 6\u2005months, and 12\u2005months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dupilumab was associated with progressive improvement in EOM-related outcomes. Median COMOT-15 decreased from 49 at baseline to 20 at 6\u2005months and 15 at 12 months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Tympanometry improved from 32 type B and 16 type C patterns at baseline to predominantly type A patterns at 12\u2005months. Sinonasal outcomes also improved: median NPS decreased from 6 to 3 and 2, SNOT-22 from 68 to 28 and 22, and VAS nasal congestion from 8 to 2 and 1 at 6 and 12\u2005months, respectively (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Peripheral eosinophil counts did not significantly decrease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with severe CRSwNP and concomitant EOM, dupilumab was associated with sustained 12-month improvement in EOM-related quality of life and tympanometric patterns, supporting further investigation within a one-airway-one-ear type 2 framework.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19458924261480415","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:56:29Z","timestamp":1789134989000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Twelve-Month Effectiveness of Dupilumab on Eosinophilic Otitis Media in Patients with Severe Chronic Rhinosinusitis with Nasal Polyps: A Multicenter Observational Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-4596","authenticated-orcid":false,"given":"Cosimo","family":"Galletti","sequence":"first","affiliation":[{"name":"University Kore of Enna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Stilo","sequence":"additional","affiliation":[{"name":"University of Catania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Sireci","sequence":"additional","affiliation":[{"name":"University of Palermo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Giammona Indaco","sequence":"additional","affiliation":[{"name":"University Kore of Enna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2134-8535","authenticated-orcid":false,"given":"Daniele","family":"Portelli","sequence":"additional","affiliation":[{"name":"University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonietta","family":"Barbieri","sequence":"additional","affiliation":[{"name":"University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Frangipane","sequence":"additional","affiliation":[{"name":"University of Catania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Giunta","sequence":"additional","affiliation":[{"name":"University of Catania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Manzella","sequence":"additional","affiliation":[{"name":"University of Palermo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Ferrisi","sequence":"additional","affiliation":[{"name":"University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Immordino","sequence":"additional","affiliation":[{"name":"University of 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