{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:01:10Z","timestamp":1785765670703,"version":"3.56.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Bone marrow stimulation surgeries are frequent in the treatment of cartilage lesions. Autologous chondrocyte implantation (ACI) may be performed after failed microfracture surgery. Alterations to subchondral bone as intralesional osteophytes are commonly seen after previous microfracture and removed during ACI. There have been no reports on potential recurrence. Our purpose was to evaluate the incidence of intralesional osteophyte development in 2 cohorts: existing intralesional osteophytes and without intralesional osteophytes at the time of ACI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We identified 87 patients (157 lesions) with intralesional osteophytes among a cohort of 497 ACI patients. Osteophyte regrowth was analyzed on magnetic resonance imaging and categorized as small or large (less or more than 50% of the cartilage thickness). Twenty patients (24 defects) without intralesional osteophytes at the time of ACI acted as control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Osteophyte regrowth was observed in 39.5% of lesions (34.4% of small osteophytes and 5.1% of large osteophytes). In subgroup analyses, regrowth was observed in 45.8% of periosteal-covered defects and in 18.9% of collagen membrane\u2013covered defects. Large osteophyte regrowth occurred in less than 5% in either group. Periosteal defects showed a significantly higher incidence for regrowth of small osteophytes. In the control group, intralesional osteophytes developed in 16.7% of the lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Even though intralesional osteophytes may regrow after removal during ACI, most of them are small. Small osteophyte regrowth occurs almost twice in periosteum-covered ACI. Large osteophytes occur only in 5% of patients. Intralesional osteophyte formation is not significantly different in preexisting intralesional osteophytes and control groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603516653208","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T21:30:41Z","timestamp":1466631041000},"page":"131-138","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Intralesional Osteophyte Regrowth Following Autologous Chondrocyte Implantation after Previous Treatment with Marrow Stimulation Technique"],"prefix":"10.1177","volume":"8","author":[{"given":"Marco Kawamura","family":"Demange","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Minas","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Brigham & Women\u2019s Hospital, Chestnut Hill, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"von Keudell","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Brigham & Women\u2019s Hospital, Chestnut Hill, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Sodha","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Bryant","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas H.","family":"Gomoll","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Brigham & Women\u2019s Hospital, Chestnut Hill, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"bibr1-1947603516653208","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1998.28.4.192"},{"key":"bibr2-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509352157"},{"key":"bibr3-1947603516653208","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02846"},{"key":"bibr4-1947603516653208","doi-asserted-by":"crossref","unstructured":"Frisbie DD, Oxford JT, Southwood L, Trotter GW, Rodkey WG, Steadman JR, Early events in cartilage repair after subchondral bone microfracture. Clin Orthop Relat Res. 2003;(407):215-27.","DOI":"10.1097\/00003086-200302000-00031"},{"key":"bibr5-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200110001-00033"},{"issue":"14","key":"bibr6-1947603516653208","first-page":"2470","volume":"92","author":"Gomoll AH","year":"2010","journal-title":"J Bone Joint Surg Am"},{"key":"bibr7-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-010-1072-x"},{"key":"bibr8-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.058347"},{"key":"bibr9-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(03)00061-9"},{"issue":"213","key":"bibr10-1947603516653208","first-page":"34","author":"Radin EL","year":"1986","journal-title":"Clin Orthop Relat Res"},{"key":"bibr11-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509360403"},{"key":"bibr12-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2003.50112"},{"key":"bibr13-1947603516653208","doi-asserted-by":"crossref","unstructured":"Kreuz PC, Steinwachs MR, Erggelet C, Krause SJ, Konrad G, Uhl M, Results after microfracture of full-thickness chondral defects in different compartments in the knee. Osteoarthritis Cartilage. 2006;14(11):1119-25.","DOI":"10.1016\/j.joca.2006.05.003"},{"key":"bibr14-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508330137"},{"key":"bibr15-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511425651"},{"key":"bibr16-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3146-9"},{"key":"bibr17-1947603516653208","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300002-00003"},{"key":"bibr18-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509348477"},{"key":"bibr19-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-6654-5.00014-6"},{"key":"bibr20-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508328414"},{"key":"bibr21-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1177\/0363546506289882"},{"key":"bibr22-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509350694"},{"key":"bibr23-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2004.12.008"},{"key":"bibr24-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(84)90075-7"},{"key":"bibr25-1947603516653208","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000100027"}],"container-title":["CARTILAGE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1947603516653208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1947603516653208","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1947603516653208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:01:05Z","timestamp":1777384865000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1947603516653208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1177\/1947603516653208"],"URL":"https:\/\/doi.org\/10.1177\/1947603516653208","relation":{},"ISSN":["1947-6035","1947-6043"],"issn-type":[{"value":"1947-6035","type":"print"},{"value":"1947-6043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,7]]}}}