{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:54:42Z","timestamp":1777478082751,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,12,4]],"date-time":"2016-12-04T00:00:00Z","timestamp":1480809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to determine whether intra-articular injections of tenascin-C (TNC) could prevent cartilage damage in murine models of osteoarthritis (OA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Fluorescently labeled TNC was injected into knee joints and its distribution was examined at 1 day, 4 days, 1 week, 2 weeks, and 4 weeks postinjection. To investigate the effects of TNC on cartilage degeneration after surgery to knee joints, articular spaces were filled with 100 \u03bcg\/mL (group I), 10 \u03bcg\/mL (group II) of TNC solution, or control (group III). TNC solution of 10 \u03bcg\/mL was additionally injected twice after 3 weeks (group IV) or weekly after 1 week, 2 weeks, and 3 weeks (group V). Joint tissues were histologically assessed using the Mankin score and the modified Chambers system at 2 to 8 weeks after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Exogenous TNC was maintained in the cartilage and synovium for 1 week after administration. Histological scores in groups I and II were better than scores in group III at 4 and 6 weeks, but progressive cartilage damage was seen in all groups 8 weeks postoperatively. Sequential TNC injections (groups IV and V) showed significantly better Mankin score than single injection (group II) at 8 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TNC administered exogenously remained in the cartilage of knee joints for 1 week, and could decelerate articular cartilage degeneration in murine models of OA. We also showed that sequential administration of TNC was more effective than a single injection. TNC could be an important molecule for prevention of articular cartilage damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603516681134","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T20:55:21Z","timestamp":1480712121000},"page":"80-88","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Tenascin-C Prevents Articular Cartilage Degeneration in Murine Osteoarthritis Models"],"prefix":"10.1177","volume":"9","author":[{"given":"Yuriyo","family":"Matsui","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Iino","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Imanaka-Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology & Matrix Biology, Mie University Graduate School of Medicine, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology & Matrix Biology, Mie University Graduate School of Medicine, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Sudo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,12,4]]},"reference":[{"key":"bibr1-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1997.0086"},{"key":"bibr2-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0310"},{"key":"bibr3-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1186\/ar3286"},{"key":"bibr4-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(03)00119-5"},{"key":"bibr5-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.007"},{"key":"bibr6-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1186\/ar2521"},{"key":"bibr7-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20840"},{"key":"bibr8-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21165"},{"key":"bibr9-1947603516681134","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11104106"},{"key":"bibr10-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-013-0010-0"},{"key":"bibr11-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.08.002"},{"key":"bibr12-1947603516681134","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100213"},{"key":"bibr13-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.770837"},{"key":"bibr14-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90374-0"},{"key":"bibr15-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(93)90037-Q"},{"key":"bibr16-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1007\/BF01921736"},{"key":"bibr17-1947603516681134","first-page":"577","volume":"15","author":"Belanger I","year":"2000","journal-title":"Histol Histopathol"},{"key":"bibr18-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19981015)43:2<102::AID-JEMT3>3.0.CO;2-T"},{"key":"bibr19-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2002.003749"},{"key":"bibr20-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/32.9.780"},{"key":"bibr21-1947603516681134","doi-asserted-by":"publisher","DOI":"10.1080\/rhe.31.3.151.157"},{"key":"bibr22-1947603516681134","unstructured":"Hasegawa M, Hirata H, Sudo A, Kato K, Kawase D, Kinoshita N, et al. 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