{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:34:56Z","timestamp":1789544096018,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Fundaci\u00f3n Doctor Pedro Guill\u00e9n"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Objective<\/jats:italic>\n                    . The aim of this work was to study the short- and mid-term effectiveness and safety of high-density autologous chondrocyte implantation (HD-ACI) in the first 50 patients with knee cartilage damage treated in our unit.\n                    <jats:italic toggle=\"yes\">Design<\/jats:italic>\n                    . Fifty consecutive patients with cartilage lesions (Outerbridge grade III-IV) in the knee treated with HD-ACI were included in this study. Chondrocytes were isolated from a nonbearing cartilage area biopsy and were cultured until 40 to 50 million cells were obtained. Five million chondrocytes per cm\n                    <jats:sup>2<\/jats:sup>\n                    of a porcine collagen type I\/III membrane were implanted covering the defect. Procedure effectiveness was assessed by evaluating pain, swelling, and range of mobility (flexion and extension) at 6-, 12-, and 24-month follow-up. The International Knee Documentation Committee (IKDC) subjective evaluation form was used to evaluate symptoms and functions of the knee.\n                    <jats:italic toggle=\"yes\">Results<\/jats:italic>\n                    . The percentage of patients with pain and swelling decreased progressively in the following visits, with differences being statistically significant (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001 and\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.040, respectively). IKDC scores improved progressively throughout the 24-month follow-up (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). Thus, the mean IKDC score improvement was 26.3 points (95% confidence interval [CI] = 18.2-34.4 points) at 12 months and 31.0 points (95% CI = 22.9-39 points) at 24 months. No significant differences were found when performing extension (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.112). Flexion significantly improved by 25.1\u00b0 at 24-month follow-up (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.013).\n                    <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>\n                    . HD-ACI is a safe and effective technique for the treatment of cartilage defects, improving clinical and subjective perception of knee functionality. These preliminary results encourage future studies comparing this technique with traditional ACI.\n                  <\/jats:p>","DOI":"10.1177\/1947603517693045","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:58:39Z","timestamp":1487206719000},"page":"363-369","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Cartilage Defect Treatment Using High-Density Autologous Chondrocyte Implantation"],"prefix":"10.1177","volume":"9","author":[{"given":"Juan Manuel","family":"Lopez-Alcorocho","sequence":"first","affiliation":[{"name":"Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Aboli","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Guillen-Vicente","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rodriguez-I\u00f1igo","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Guillen-Vicente","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s F.","family":"Fern\u00e1ndez-Ja\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Arauz","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Abelow","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Guillen-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Research Unit, Clinica CEMTRO, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2002.32839"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2007.02.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1308\/003588412X13171221592573"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2014.10.007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514547029"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200110001-00033"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2011.04.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2016.01.017."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311401"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2008.01.040"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200005000-00020"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.04.020"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/272481."},{"key":"e_1_3_2_15_2","article-title":"Autologous chondrocyte implantation at the knee using a bilayer collagen membrane with bone graft. 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