{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:05:01Z","timestamp":1790737501872,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 RX000700"],"award-info":[{"award-number":["I01 RX000700"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 RX001213"],"award-info":[{"award-number":["I01 RX001213"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001702","name":"AO Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To test different fixation methods of a 3-dimensionally woven poly(\u03f5-caprolactone) (PCL) scaffold within chondral defects of a weightbearing large animal model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Full thickness chondral defects were made in the femoral condyles of 15 adult male Yucatan mini-pigs. Two surgical approaches were compared including total arthrotomy (traditional) and a retinaculum-sparing, minimally invasive surgery (MIS) approach. Following microfracture (MFX), scaffolds were placed without fixation or were fixed with fibrin glue, suture, or subchondral anchor. Experimental endpoints were between 1 and 6 weeks. Micro\u2013computed tomography and histology were used to assess samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The MIS approach was superior as the traditional approach caused medial condyle cartilage wear. One of 13 (7.7%) of scaffolds without fixation, 4 of 11 (36.3%) fibrin scaffolds, 1 of 4 (25%) of sutured scaffolds, and 9 of 9 (100%) of anchor-fixed scaffolds remained in place. Histology demonstrated tissue filling with some overgrowth of PCL scaffolds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Of the methods tested, the MIS approach coupled with subchondral anchor fixation provided the best scaffold retention in a mini-pig chondral defect model. This finding has implications for fixation strategies in future animal studies and potential future human use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603517700953","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T06:10:05Z","timestamp":1491891005000},"page":"428-437","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Comparison of Fixation Techniques of 3D-Woven Poly(\u03f5-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model"],"prefix":"10.1177","volume":"9","author":[{"given":"James M.","family":"Friedman","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, McKay Orthopaedic Research Lab, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Translational Musculoskeletal Research Center, Philadelphia VA Medical Center, Philadelphia, PA, 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L.","family":"Neuwirth","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, McKay Orthopaedic Research Lab, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niobra","family":"Keah","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, McKay Orthopaedic Research Lab, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, McKay Orthopaedic Research Lab, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin T.","family":"Moutos","sequence":"additional","affiliation":[{"name":"Cytex Therapeutics, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley 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