{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:54:56Z","timestamp":1777478096848,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Inlay arthroplasty (IA) has seen growing interest as a new primary arthroplasty intervention for patients that need to transition from biology to joint replacement. The purpose of this study was to investigate the biological response to this procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Patients presenting with symptomatic mono- or bicompartmental arthrosis and varus malalignment underwent IA and concurrent medial open wedge high tibial osteotomy (HTO). A subset of patients required hardware removal and consented to second-look arthroscopy without biopsy allowing for assessment of IA components and compartment-specific findings related to implant fixation, cartilage flow, propagation of lesions, and opposing tibial surfaces.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In a series of 41 knees (35 patients) treated with combined IA and HTO (mean varus &gt;7\u00b0), 26 knees (23 patients, 18 male, 5 female) with a mean age of 52 years (range = 43-67) required HTO plate removal. Concurrent second look arthroscopy was performed at a mean of 14 months (range = 12-19) following the index procedure. On probing, all arthroplasty components showed solid fixation without gap formation. On the medial femoral condyle, 15 mm implants (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 14) showed a peripheral cartilage flow of 12% (range = 5% to 25%), 20 mm implants (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 12) of 9% (range 5% to 15%), and trochlear implants (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 12) of 20% (range 10% to 40%). No progressive deterioration of the index defects or progression of tibial and retropatellar grades were seen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Joint surface reconstruction using IA showed stable fixation with peripheral cartilage coverage ranging from 9% to 20% and no further chondral damage on opposing surfaces. Future clinical effectiveness studies are required to support the positive biological integration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603517746723","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T01:40:20Z","timestamp":1513647620000},"page":"156-160","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Biological Response Following Inlay Arthroplasty of the Knee: Cartilage Flow Over the Implant"],"prefix":"10.1177","volume":"9","author":[{"given":"Tahsin","family":"Beyzadeoglu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Halic University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuna","family":"Pehlivanoglu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-011-1323-4."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(97)90124-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2002.32839"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20120."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311401"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509349765."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21148."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei108."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200101000-00008"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2007.05.018."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3928\/0147-7447-19980701-05"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.00003."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2009.12.028."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2556-4."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300002-00004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0998-0."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546503259301."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(20)30753-7"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546504263234."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2003.50112."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-007-0416-7."},{"key":"e_1_3_2_23_2","first-page":"18","article-title":"Review of arthroscopic and histological findings following knee inlay arthroplasty","volume":"25","author":"Markarian GG","year":"2013","unstructured":"Markarian GG, Kambour MT, Uribe JT. 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