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Arthrocentesis was performed twice on 6 patients with an isolated acute ACL tear at a mean of 6 and 14 days postinjury. Synovial fluid was analyzed by a highly multiplexed assay of 1129 proteins (SOMAscan version 3, SomaLogic, Inc., Boulder, CO). Pathway analysis using DAVID was performed; genes included met 3 criteria: significant change between the 2 study time points using a paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test, significant change between the 2 study time points using a Mann-Whitney nonparametric test, and significant Benjamini\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen analytes demonstrated significant increases between time points. Five of the 15 have been previously associated with the onset and\/or severity of rheumatoid arthritis, including apoliopoprotein E and isoform E3, vascular cell adhesion protein 1, interleukin-34, and cell surface glycoprotein CD200 receptor 1. Chondrodegenerative enzymes and products of cartilage degeneration all increased over time following injury: MMP-1 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.08, standardized response mean [SRM] = 1.00), MMP-3 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.05, SRM = 0.90), ADAM12 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03, SRM = 1.31), aggrecan (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.08, SRM = 1.13), and CTX-II (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.07, SRM = 0.56). Notable pathways that were differentially expressed following injury were the cytokine-cytokine receptor interaction and osteoclast differentiation pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The proteomic results and pathway analysis demonstrated a pattern of cartilage degeneration, not only consistent with previous findings but also changes consistent with an inflammatory arthritogenic process post-ACL injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603518790009","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T01:01:53Z","timestamp":1532307713000},"page":"329-337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Joint Fluid Proteome after Anterior Cruciate Ligament Rupture Reflects an Acute Posttraumatic Inflammatory and Chondrodegenerative State"],"prefix":"10.1177","volume":"11","author":[{"given":"John D.","family":"King","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Rowland","sequence":"additional","affiliation":[{"name":"Central Texas Sports Medicine &amp; Orthopedics, Bryan, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro G.","family":"Villasante Tezanos","sequence":"additional","affiliation":[{"name":"College of Health Sciences, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Warwick","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia B.","family":"Kraus","sequence":"additional","affiliation":[{"name":"Duke Molecular Physiology Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA"},{"name":"Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lattermann","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Harvard Medical School and Brigham and Women\u2019s Hosptial, Chestnut Hill, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cale A.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2008.08.009"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20101"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1538"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21215"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B10.18907"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.06.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11326"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0160(02)00083-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-014-0448-1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.07.021"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22208"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23329"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516666818"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2014.01.007"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.03.002"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.08.005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2014.08.012"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep31727"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39146"},{"issue":"6","key":"e_1_3_2_21_2","article-title":"Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis","volume":"70","author":"Martel-Pelletier J","year":"1994","unstructured":"Martel-Pelletier J, McCollum R, Fujimoto N, Obata K, Cloutier JM, Pelletier JP. 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