{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:14:52Z","timestamp":1793330092888,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["95110008"],"award-info":[{"award-number":["95110008"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Both, knee joint distraction (KJD) and high tibial osteotomy (HTO) are joint-preserving surgeries that postpone total knee arthroplasty (TKA) in younger osteoarthritis (OA) patients. Here we evaluate the 2-year follow-up of KJD versus TKA and KJD versus HTO in 2 noninferiority studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Knee OA patients indicated for TKA were randomized to KJD ( n = 20; KJD\n                      <jats:sub>TKA<\/jats:sub>\n                      ) or TKA ( n = 40). Medial compartmental knee OA patients considered for HTO were randomized to KJD ( n = 23; KJD\n                      <jats:sub>HTO<\/jats:sub>\n                      ) or HTO ( n = 46). Patient-reported outcome measures were assessed over 2 years of follow-up. The radiographic joint space width (JSW) was measured yearly. In the KJD groups, serum-PIIANP and urinary-CTXII levels were measured as collagen type-II synthesis and breakdown markers. It was hypothesized that there was no clinically important difference in the primary outcome, the total WOMAC, when comparing KJD with HTO and with TKA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both trials were completed, with 114 patients (19 KJD\n                      <jats:sub>TKA<\/jats:sub>\n                      ; 34 TKA; 20 KJD\n                      <jats:sub>HTO<\/jats:sub>\n                      ; 41 HTO) available for 2-year analyses. At 2 years, the total WOMAC score (KJDTKA: +38.9 [95%CI 28.8-48.9] points; TKA: +42.1 [34.5-49.7]; KJDHTO: +26.8 [17.1-36.6]; HTO: +34.4 [28.0-40.7]; all: P &lt; 0.05) and radiographic minimum JSW (KJDTKA: +0.9 [0.2-1.6] mm; KJDHTO: +0.9 [0.5-1.4]; HTO: +0.6 [0.3-0.9]; all: P &lt; 0.05) were still increased for all groups. The net collagen type-II synthesis 2 years after KJD was increased ( P &lt; 0.05). Half of KJD patients experienced pin tract infections, successfully treated with oral antibiotics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sustained improvement of clinical benefit and (hyaline) cartilage thickness increase after KJD is demonstrated. KJD was clinically noninferior to HTO and TKA in the primary outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603519828432","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T20:32:15Z","timestamp":1550089935000},"page":"181-191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Knee Joint Distraction Compared with High Tibial Osteotomy and Total Knee Arthroplasty: Two-Year Clinical, Radiographic, and Biochemical Marker Outcomes of Two Randomized Controlled Trials"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1929-6350","authenticated-orcid":false,"given":"Myl\u00e8ne P.","family":"Jansen","sequence":"first","affiliation":[{"name":"Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-9603","authenticated-orcid":false,"given":"Nick J.","family":"Besselink","sequence":"additional","affiliation":[{"name":"Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"van Heerwaarden","sequence":"additional","affiliation":[{"name":"Centre for Deformity Correction and Joint Preserving Surgery, Kliniek ViaSana, Mill, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel J. H.","family":"Custers","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J.","family":"Emans","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Maastricht University Medical Center, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Spruijt","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, HagaZiekenhuis, The Hague, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Mastbergen","sequence":"additional","affiliation":[{"name":"Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris P. J. G.","family":"Lafeber","sequence":"additional","affiliation":[{"name":"Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"bibr1-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0834-6"},{"key":"bibr2-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.29"},{"key":"bibr3-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-46"},{"key":"bibr4-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B11.29601"},{"key":"bibr5-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2014.11.035"},{"key":"bibr6-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2013.10.008"},{"key":"bibr7-1947603519828432","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1055\/s-0031-1298388","volume":"150","author":"Spahn G","year":"2012","journal-title":"Z Orthop Unfall"},{"key":"bibr8-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.142364"},{"key":"bibr9-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.08.006"},{"key":"bibr10-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1177\/1947603516665442"},{"key":"bibr11-1947603519828432","doi-asserted-by":"publisher","DOI":"10.17554\/j.issn.2311-5106.2015.02.91"},{"key":"bibr12-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-016-4131-0"},{"key":"bibr13-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.99B1.BJJ-2016-0099.R3"},{"key":"bibr14-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.09.001"},{"key":"bibr15-1947603519828432","first-page":"261","volume":"53","author":"Martineau PA","year":"2010","journal-title":"Can J Surg"},{"key":"bibr16-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.06.009"},{"key":"bibr17-1947603519828432","doi-asserted-by":"publisher","DOI":"10.17352\/2455-2968.000016"},{"key":"bibr18-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155524"},{"key":"bibr19-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-016-2609-3"},{"issue":"12","key":"bibr20-1947603519828432","first-page":"CD004551","author":"Lethaby A","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr21-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1007\/s11751-016-0256-4"},{"key":"bibr22-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.08.004"},{"key":"bibr23-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.02.005"},{"key":"bibr24-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1002\/art.38906"},{"key":"bibr25-1947603519828432","doi-asserted-by":"publisher","DOI":"10.1177\/1947603518777578"}],"container-title":["CARTILAGE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1947603519828432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1947603519828432","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1947603519828432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:01:40Z","timestamp":1777384900000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1947603519828432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,13]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1177\/1947603519828432"],"URL":"https:\/\/doi.org\/10.1177\/1947603519828432","relation":{},"ISSN":["1947-6035","1947-6043"],"issn-type":[{"value":"1947-6035","type":"print"},{"value":"1947-6043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,13]]}}}