{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:23:13Z","timestamp":1790468593769,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2014-04586"],"award-info":[{"award-number":["RGPIN-2014-04586"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["201309MOP-311542-DIB-CBBA-170939"],"award-info":[{"award-number":["201309MOP-311542-DIB-CBBA-170939"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Recent studies have implicated the cyclin dependent kinase inhibitor, p21, in enhanced tissue regeneration observed in MRL\/MpJ \u201csuper-healer\u201d mice. Specifically, p21 is downregulated in MRL cells and similar ear hole closure to MRL mice has been observed in p21\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice. However, the direct implications of p21 deletion in endogenous articular cartilage regeneration remain unknown. In this study, we investigated the role of p21 deletion in the ability of mice to heal full-thickness cartilage defects (FTCDs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      C57BL\/6 and p21\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ( Cdkn1a\n                      <jats:sup>tm1Tyj<\/jats:sup>\n                      ) mice were subjected to FTCD and assessment of cartilage healing was performed at 1 hour, 3 days, 1 week, 2 weeks, and 4 weeks post-FTCD using a 14-point histological scoring system. X-ray microscopy was used to quantify cartilage healing parameters (e.g., cartilage thickness, surface area\/volume) between C57BL\/6 and p21\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Absence of p21 resulted in increased spontaneous articular cartilage regeneration by 3 days post-FTCD. Furthermore, p21\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice presented with increased cartilage thickness at 1 and 2 weeks post-FTCD compared with uninjured controls, returning to baseline by 4 weeks post-FTCD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We report that p21\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice display enhanced articular cartilage regeneration post-FTCD compared with C57BL\/6 mice. Furthermore, cartilage thickness was increased in p21\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice at 1 week post-FTCD compared with uninjured p21\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice and C57BL\/6 mice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603519876348","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T20:21:55Z","timestamp":1569529315000},"page":"1608S-1617S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["p21\n                    <sup>\u2212\/\u2212<\/sup>\n                    Mice Exhibit Spontaneous Articular Cartilage Regeneration Post-Injury"],"prefix":"10.1177","volume":"13","author":[{"given":"Christina L.","family":"Jablonski","sequence":"first","affiliation":[{"name":"McCaig Institute for Bone & Joint Health, University of Calgary, Calgary, Alberta, Canada"},{"name":"Biomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce A.","family":"Besler","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone & Joint Health, University of Calgary, Calgary, Alberta, Canada"},{"name":"Biomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahaan","family":"Ali","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone & Joint Health, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2576-4504","authenticated-orcid":false,"given":"Roman J.","family":"Krawetz","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone & Joint Health, University of Calgary, Calgary, Alberta, Canada"},{"name":"Biomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Surgery, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Anatomy and Cell Biology, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,26]]},"reference":[{"key":"bibr1-1947603519876348","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.08.027"},{"key":"bibr2-1947603519876348","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.31.Suppl_12.7"},{"key":"bibr3-1947603519876348","doi-asserted-by":"publisher","DOI":"10.1177\/1941738109350438"},{"key":"bibr4-1947603519876348","first-page":"477","volume":"47","author":"Buckwalter JA","year":"1998","journal-title":"Instr Course 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