{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:18:33Z","timestamp":1783981113195,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Osteoarthritis (OA) is a prevalent chronic multifactorial degenerative disease characterized by joint tissue inflammation, osteophyte formation, subchondral bone sclerosis, and articular cartilage degradation. Low-intensity pulsed ultrasound (LIPUS), a noninvasive ultrasound technique, is widely used to attenuate diseases. The aim of this study was to investigate whether LIPUS can ameliorate OA, and to explore its underlying molecular mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The OA model was established in a C57BL\/6 mouse by the anterior cruciate ligament transaction method. OA was assessed using arthritis scoring and weightbearing parameters. Chondrocyte proliferation was detected by a CCK-8 assay. The levels of interleukin-6 (IL-6), IL-8 and tumor necrosis factor-\u03b1 (TNF-\u03b1) in synovial fluid of the mice were measured by enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In OA mice, the arthritis score and weightbearing abilities were dramatically improved by LIPUS treatment. LIPUS also remarkably declined the levels of inflammatory cytokines IL-6, IL-8, and TNF-\u03b1 in synovial fluid of OA mice. Moreover, LIPUS promoted chondrocyte proliferation and differentiation by activating focal adhesion kinase (FAK) signaling. Inhibition of FAK significantly blocked LIPUS-mediated cell proliferation and differentiation in vitro, as well as inflammation condition in OA mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LIPUS alleviates OA through promoting chondrocytes proliferation and differentiation by activating FAK, which could act as an intervening target for OA treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603520912322","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T07:14:13Z","timestamp":1586762053000},"page":"196S-203S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Low-Intensity Pulsed Ultrasound Alleviates Osteoarthritis Condition Through Focal Adhesion Kinase\u2013Mediated Chondrocyte Proliferation and Differentiation"],"prefix":"10.1177","volume":"13","author":[{"given":"Fei","family":"Sang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Lianshui County People\u2019s Hospital, The Affiliated Lianshui County People\u2019s Hospital of Kangda College of Nanjing Medical University, Huai\u2019an, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Affiliated Huai\u2019an Hospital of Xuzhou Medical University and The Second People\u2019s Hospital of Huai\u2019an, Huai\u2019an, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Surgery, The Affiliated Huai\u2019an No. 1 People\u2019s Hospital of Nanjing Medical University, Huai\u2019an, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Lianshui County People\u2019s Hospital, The Affiliated Lianshui County People\u2019s Hospital of Kangda College of Nanjing Medical University, Huai\u2019an, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Wujin Hospital Affiliated with Jiangsu University, the Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,4,13]]},"reference":[{"key":"bibr1-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1186\/ar4405"},{"key":"bibr2-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3087-7"},{"key":"bibr3-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1002\/art.23614"},{"key":"bibr4-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1998"},{"key":"bibr5-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2055"},{"key":"bibr6-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080901"},{"key":"bibr7-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2146"},{"key":"bibr8-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2153"},{"key":"bibr9-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2006.07.021"},{"key":"bibr10-1947603520912322","volume":"10","author":"Xu T","year":"2018","journal-title":"Am J Transl Res"},{"key":"bibr11-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2019.08.025"},{"key":"bibr12-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-019-01029-5"},{"key":"bibr13-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.08.005"},{"key":"bibr14-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2010.11.016"},{"key":"bibr15-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106722"},{"key":"bibr16-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0884"},{"key":"bibr17-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.02.015"},{"key":"bibr18-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.06.088"},{"key":"bibr19-1947603520912322","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.14.10016"},{"key":"bibr20-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(05)80318-8"},{"key":"bibr21-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.08.023"},{"key":"bibr22-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1186\/ar1179"},{"key":"bibr23-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2908"},{"key":"bibr24-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0408-0"},{"key":"bibr25-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-008-9872-5"},{"key":"bibr26-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12383"},{"key":"bibr27-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultras.2014.01.004"},{"key":"bibr28-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095168"},{"key":"bibr29-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-010-0104-5"},{"key":"bibr30-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20187862"},{"key":"bibr31-1947603520912322","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.136"}],"container-title":["CARTILAGE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1947603520912322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1947603520912322","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1947603520912322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:02:06Z","timestamp":1777384926000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1947603520912322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,13]]},"references-count":31,"journal-issue":{"issue":"2_suppl","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1177\/1947603520912322"],"URL":"https:\/\/doi.org\/10.1177\/1947603520912322","relation":{},"ISSN":["1947-6035","1947-6043"],"issn-type":[{"value":"1947-6035","type":"print"},{"value":"1947-6043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,13]]}}}