{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:57:59Z","timestamp":1777478279464,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EC1408D -OVERLOAD-PREVOP"],"award-info":[{"award-number":["01EC1408D -OVERLOAD-PREVOP"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To test the hypothesis that superficial cartilage composition (T2) is associated with subsequent incidence or worsening of cartilage damage, and deep T2 with that of bone marrow lesions (BMLs) in knees without radiographic osteoarthritis (ROA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A total of 201 knees from the Osteoarthritis Initiative without ROA were included: 78 from the healthy reference cohort, 60 without ROA but with risk factors, and 63 without ROA but with contralateral ROA. Year 1 (Y1) superficial and deep cartilage T2 were derived in the medial and lateral (weightbearing) femur (MF\/LF) and tibia (MT\/LT), using sagittal multiecho spin echo magnetic resonance images. Cartilage and BMLs were assessed in the medial (MFTJ) and lateral femorotibial joint (LFTJ) at Y1 and 3 years later. Binary logistic regression statistics were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Incidence or worsening of cartilage damage was more frequent (MFTJ 15%, LFTJ 13%) than incidence or worsening of BMLs (6.0%, 4.5%). In knees with incident or worsening cartilage lesions in the MF and LT, deep layer T2 in the same plate was elevated (MF, 43.6 \u00b1 4.0 vs. 41.3 \u00b1 3.8 ms, P = 0.047; LT, 33.8 \u00b1 2.3 vs. 32.0 \u00b1 2.2 ms, P = 0.008) compared to those without. In knees with incident or worsening of BMLs in the LFTC and LT, superficial layer T2 was elevated (LFTJ, 49.6 \u00b1 4.8 vs. 46.7 \u00b1 3.1 ms; LT, 47.4 \u00b1 4.9 vs. 44.0 \u00b1 3.3 ms, both Ps = 0.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Contrary to our hypothesis, increased deep layer cartilage T2 was associated with subsequent worsening of cartilage damage, whereas superficial layer T2 was related to subsequent BML worsening. Yet, this relationship was observed in some, but not in all cartilage plates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603520932197","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T04:11:33Z","timestamp":1591935093000},"page":"757S-766S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Is Laminar Cartilage Composition as Determined by T2 Relaxometry Associated with Incident and Worsening of Cartilage or Bone Marrow Abnormalities?"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-7350","authenticated-orcid":false,"given":"Frank W.","family":"Roemer","sequence":"first","affiliation":[{"name":"Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA"},{"name":"Department of Radiology, Friedrich-Alexander University Erlangen-N\u00fcrnberg (FAU) and Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Chondrometrics GmbH, Ainring, Germany"},{"name":"Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria"},{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Duda","sequence":"additional","affiliation":[{"name":"Julius Wolff Institute and Berlin Institute of Health Center for Regenerative Therapies, Charit\u00e9-Universit\u00e4tsmedizin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA"},{"name":"Department of Radiology, VA Boston Healthcare System, West Roxbury, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Maschek","sequence":"additional","affiliation":[{"name":"Chondrometrics GmbH, Ainring, Germany"},{"name":"Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5571-1622","authenticated-orcid":false,"given":"Leena","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Wirth","sequence":"additional","affiliation":[{"name":"Chondrometrics GmbH, Ainring, Germany"},{"name":"Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria"},{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"bibr1-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.05.026"},{"key":"bibr2-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2322030976"},{"key":"bibr3-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20672"},{"key":"bibr4-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1038\/srep34202"},{"key":"bibr5-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.013"},{"key":"bibr6-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204157"},{"key":"bibr7-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.10.016"},{"key":"bibr8-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2019.100014"},{"key":"bibr9-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5339"},{"key":"bibr10-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1002\/art.39176"},{"key":"bibr11-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.05.014"},{"key":"bibr12-1947603520932197","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0543-0"},{"key":"bibr13-1947603520932197","unstructured":"Nevitt MC, Felson DT, Lester G. 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