{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:26:30Z","timestamp":1785173190289,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_175660\/1"],"award-info":[{"award-number":["310030_175660\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PMPDP3_151396\/1"],"award-info":[{"award-number":["PMPDP3_151396\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stiftung Lindenhof Bern, Switzerland","award":["14-05-F"],"award-info":[{"award-number":["14-05-F"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Cellular and molecular events occurring in cartilage regions close to injury are poorly investigated, but can possibly compromise the outcome of cell-based cartilage repair. In this study, key functional properties were assessed for cartilage biopsies collected from the central part of traumatic joint lesions (\n                      <jats:italic toggle=\"yes\">central<\/jats:italic>\n                      ) and from regions surrounding the defect (\n                      <jats:italic toggle=\"yes\">peripheral<\/jats:italic>\n                      ). These properties were then correlated with the quality of the initial cartilage biopsy and the inflammatory state of the joint.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cartilage samples were collected from knee joints of 42 patients with traumatic knee injuries and analyzed for cell phenotype (by reverse transcriptas-polymerase chain reaction), histological quality, cellularity, cell viability, proliferation capacity, and post-expansion chondrogenic capacity of chondrocytes (in pellet culture). Synovium was also harvested and analyzed for the expression of inflammatory cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cartilage quality and post-expansion chondrogenic capacity were higher in\n                      <jats:italic toggle=\"yes\">peripheral<\/jats:italic>\n                      versus\n                      <jats:italic toggle=\"yes\">central<\/jats:italic>\n                      samples. Differences between these 2 parameters were more pronounced in joints with high inflammatory features characterized by &gt;100-fold difference in the mRNA levels of IL6 and IL8 in the corresponding synovium.\n                      <jats:italic toggle=\"yes\">Peripheral<\/jats:italic>\n                      chondrocytes isolated from good- versus bad-quality biopsies expressed higher levels of collagen II\/I and aggrecan\/versican and lower levels of MMP13 and ADAMTS5. They also exhibited reduced proliferation and enhanced cartilage-forming capacity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Chondrocytes at the periphery of traumatic lesions better maintain properties of healthy cartilage compared to those isolated from the center, even when derived from bad-quality tissues harvested from highly inflamed joints. Future studies are necessary to investigate the change of functional properties of\n                      <jats:italic toggle=\"yes\">peripheral<\/jats:italic>\n                      chondrocytes over time.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603520958154","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T05:31:56Z","timestamp":1600752716000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of Human Articular Cartilage Tissue and Chondrocytes Isolated from Peripheral versus Central Regions of Traumatic Lesions"],"prefix":"10.1177","volume":"13","author":[{"given":"Lina","family":"Acevedo","sequence":"first","affiliation":[{"name":"Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Iselin","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland"},{"name":"Department of Orthopedics and Traumatology, Lucerne Cantonal Hospital, Lucerne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majoska H. 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