{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:27:52Z","timestamp":1792290472270,"version":"4.4.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sagepub.com\/licence-information-for-chorus"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR073964"],"award-info":[{"award-number":["R01AR073964"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R37AG059418"],"award-info":[{"award-number":["R37AG059418"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000147","name":"Division of Civil, Mechanical and Manufacturing Innovation","doi-asserted-by":"publisher","award":["1554708"],"award-info":[{"award-number":["1554708"]}],"id":[{"id":"10.13039\/100000147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Intra-articular drug delivery holds great promise for the treatment of joint diseases such as osteoarthritis. The objective of this study was to evaluate the TAT peptide transduction domain (TAT-PTD) as a potential intra-articular drug delivery technology for synovial joints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Experiments examined the ability of TAT conjugates to associate with primary chondrocytes and alter cellular function both in vitro and in vivo. Further experiments examined the ability of the TAT-PTD to bind to human osteoarthritic cartilage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results show that the TAT-PTD associates with chondrocytes, is capable of delivering siRNA for chondrocyte gene knockdown, and that the recombinant enzyme TAT-Cre is capable of inducing in vivo genetic recombination within the knee joint in a reporter mouse model. Last, binding studies show that osteoarthritic cartilage preferentially uptakes the TAT-PTD from solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest that the TAT-PTD is a promising delivery strategy for intra-articular therapeutics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603520959392","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T06:21:36Z","timestamp":1600496496000},"page":"1637S-1645S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The TAT Protein Transduction Domain as an Intra-Articular Drug Delivery Technology"],"prefix":"10.1177","volume":"13","author":[{"given":"Sarah E.","family":"Mailhiot","sequence":"first","affiliation":[{"name":"University of Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4843-3513","authenticated-orcid":false,"given":"Matthew A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Montana State University System, Bozeman, MT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko E.","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Mie University Graduate School of Medicine Faculty of Medicine, Tsu, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina E.","family":"Dinkel","sequence":"additional","affiliation":[{"name":"Montana State University System, Bozeman, MT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin K.","family":"Lotz","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven 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