{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:55:24Z","timestamp":1787237724487,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["33123"],"award-info":[{"award-number":["33123"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The identification of early-stage osteoarthritis (OA) is crucial for the deceleration of its progression; however, no reliable biomarker is available for this purpose. The current study aimed to determine the role of serum calprotectin in the detection of early-stage knee OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>In a case-control study, serum samples were collected from 84 patients with primary bilateral knee OA and 52 healthy controls. The radiographic grading of knee OA was performed using the Kellgren-Lawrence classification system. Serum concentrations of calprotectin were measured using an enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean serum calprotectin level was 2908 \u00b1 2516 ng\/mL in OA patients and 901 \u00b1 875 ng\/mL in healthy control subjects ( P &lt; 0.001). Mean serum calprotectin levels were significantly higher in the lower stages of OA: 3740 \u00b1 2728 ng\/mL in OA grade I, 3100 \u00b1 2084 ng\/mL in OA grade II, 2246 \u00b1 1418 ng\/mL in OA grade III, and 2035 \u00b1 765 ng\/mL in OA grade IV ( P = 0.047). Serum calprotectin levels were significantly higher in patients with a disease duration &lt;42 months compared with those with a disease duration &gt;42 months ( P = 0.043).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum calprotectin level increases significantly in the early stages of OA and shows a reverse association with disease severity. Therefore, it could be suggested as a promising blood-based marker for early-stage knee OA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603520961161","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T06:55:56Z","timestamp":1601535356000},"page":"1566S-1571S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Serum Calprotectin as a Blood-Based Biomarker for Monitoring Knee Osteoarthritis at Early but Not Late Stages"],"prefix":"10.1177","volume":"13","author":[{"given":"Amin","family":"Safa","sequence":"first","affiliation":[{"name":"Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam"},{"name":"Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University, Madrid, 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