{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:28:54Z","timestamp":1777480134004,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:00:00Z","timestamp":1610755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81773372, 81573104"],"award-info":[{"award-number":["81773372, 81573104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009103","name":"education department of shaanxi province","doi-asserted-by":"publisher","award":["19JS015"],"award-info":[{"award-number":["19JS015"]}],"id":[{"id":"10.13039\/501100009103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"key research and development projects of shaanxi province","doi-asserted-by":"publisher","award":["2020SF-076"],"award-info":[{"award-number":["2020SF-076"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012594","name":"scientific research foundation of shaanxi provincial key laboratory","doi-asserted-by":"publisher","award":["2018A017"],"award-info":[{"award-number":["2018A017"]}],"id":[{"id":"10.13039\/501100012594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to analyze deoxycytidine-deoxyguanosine dinucleotide (CpGs) methylation profiles in DIO2, GPX3, and TXNRD1 promoter regions in osteoarthritis (OA) and Kashin-Beck disease (KBD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood samples were collected from 16 primary OA patients and corresponding 16 healthy individuals and analyzed for methylations in the CpGs of DIO2, GPX3, and TXNRD1 promoter regions using MALDI-TOF-MS. The methylation profiles of these regions were then compared between OA and KBD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DIO2-1_CpG_2 and DIO2-1_CpG_3 methylations were significantly lower in OA than KBD patients ( P &lt; 0.05). A similar trend was observed for GPX3-1_CpG_4, GPX3-1_CpG_7, GPX3-1_CpG_8.9.10, GPX3-1_CpG_13.14.15 and GPX3-1_CpG_16 ( P &lt; 0.05) as well as TXNRD1-1_CpG_1 and TXNRD1-1_CpG_2 methylation between OA and KBD patients ( P &lt; 0.05). However, there was no difference in methylation levels of other CpGs between the 2 groups ( P &gt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OA and KBD patients display distinct methylation profiles in the CpG sites of DIO2, GPX3, and TXNRD1 promoter regions. These findings provide a strong background and new perspective for future studies on mechanisms underlying epigenetic regulation of selenoprotein genes associated with OA and KBD diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1947603520988165","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T04:47:46Z","timestamp":1610772466000},"page":"797S-808S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Patients with Osteoarthritis and Kashin-Beck Disease Display Distinct CpG Methylation Profiles in the\n                    <i>DIO2, GPX3<\/i>\n                    , and\n                    <i>TXRND1<\/i>\n                    Promoter Regions"],"prefix":"10.1177","volume":"13","author":[{"given":"Rongqiang","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Public Health, Shaanxi University of Chinese Medicine, Xianyang, 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