{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:00:56Z","timestamp":1791687656891,"version":"4.3.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009595","name":"Service Public de Wallonie","doi-asserted-by":"publisher","award":["Convention n\u00b06905"],"award-info":[{"award-number":["Convention n\u00b06905"]}],"id":[{"id":"10.13039\/501100009595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the cross-sectional association between serum levels of Coll2-1 and Coll2-1NO2, two cartilage degradation biomarkers; the burden of magnetic resonance imaging (MRI) features and clinical outcomes; and to evaluate the predictive value of these biomarkers on progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A total of 121 subjects with knee osteoarthritis (OA) were followed during 1 year with pain, function, and MRI assessment (PRODIGE study). Type II collagen-specific biomarker Coll2-1 and its nitrated form Coll2-1NO2 were directly measured in serum using immunoassays at baseline and after 3-, 6-, and 12-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Serum Coll2-1 and Coll2-1NO2 were correlated with several baseline knee features quantified with Whole-Organ Magnetic Resonance Imaging Score (WORMS). Coll2-1 was significantly correlated with periarticular cysts\/bursitis (\u03c1 = 0.29, P &lt; 0.01), subarticular bone attrition (\u03c1 = 0.25, P = 0.01), subarticular cysts (\u03c1 = 0.24, P = 0.02), and articular cartilage integrity (\u03c1 = 0.23, P = 0.03) WORMS subscores for the whole joint as well as with the medial femorotibial joint sum score (\u03c1 = 0.26, P = 0.01) and medial femorotibial joint cartilage (\u03c1 = 0.23, P = 0.02). Coll2-1NO2 correlated with WORMS total score (\u03c1 = 0.23, P = 0.02), WORMS scores in the patellofemoral (\u03c1 = 0.23, P = 0.02) and medial femorotibial compartments (\u03c1 = 0.21, P = 0.03), with osteophytes scores (\u03c1 = 0.27, P &lt; 0.01), subarticular cysts (\u03c1 = 0.24, P = 0.019), and intraarticular loose bodies (\u03c1 = 0.27, P = 0.007). Baseline Coll2-1NO2 was higher in subjects with a pain worsening (426.4 pg\/mL [278.04-566.95]) as compared to non-progressors (306.84 pg\/mL [200.37-427.84]) over 1 year (AUC = 0.655, P = 0.015).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum cartilage biomarkers Coll2-1 and Coll2-1NO2 are associated with several knee OA features quantified with WORMS. Our study also shows that the baseline value of Coll2-1NO2 is positively associated with pain worsening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035211021892","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T05:28:56Z","timestamp":1623734936000},"page":"1637S-1647S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Cartilage Biomarkers Coll2-1 and Coll2-1NO2 Are Associated with Knee OA MRI Features and Are Helpful in Identifying Patients at Risk of Disease Worsening"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5931-052X","authenticated-orcid":false,"given":"Anne-Christine","family":"Hick","sequence":"first","affiliation":[{"name":"ARTIALIS SA, CHU Sart-Tilman, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Malaise","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU Sart Tilman, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Loeuille","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital of Nancy, Vand\u0153uvre-l\u00e8s-Nancy, France"},{"name":"UMR 7365 CNRS-Universit\u00e9 de Lorraine IMoPA, Biop\u00f4le de l\u2019Universit\u00e9 de Lorraine, Campus Brabois-Sant\u00e9, Vandoeuvre-L\u00e8s-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Conrozier","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Nord Franche-Comt\u00e9, Belfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Maugars","sequence":"additional","affiliation":[{"name":"Service de rhumatologie, H\u00f4tel-Dieu, CHU de Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Pelousse","sequence":"additional","affiliation":[{"name":"SODIRAY, Solution Diagnostique Radiologique, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Tits","sequence":"additional","affiliation":[{"name":"DNAlytics, Louvain-la-Neuve, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Henrotin","sequence":"additional","affiliation":[{"name":"ARTIALIS SA, CHU Sart-Tilman, Li\u00e8ge, Belgium"},{"name":"Bone and Cartilage Research Unit, Arthropole Li\u00e8ge, Center for Interdisciplinary Research on Medicines (CIRM), University of Li\u00e8ge, CHU Sart-Tilman, Li\u00e8ge, Belgium"},{"name":"Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Vivalia, Marche-en-Famenne, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"bibr1-19476035211021892","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.02.037"},{"key":"bibr2-19476035211021892","unstructured":"APPROACH Project. 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