{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:16:05Z","timestamp":1787019365180,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81972146"],"award-info":[{"award-number":["81972146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the anti-inflammatory effects and mechanisms of pulsed electromagnetic field (PEMF) in the treatment of osteoarthritis (OA) in the destabilization of the medial meniscus (DMM) mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Ten-week-old male wild-type (WT), interleukin (IL)-6\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      and tumor necrosis factor (TNF)-\u03b1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice undergoing DMM surgery were randomly divided into 2 groups ( n = 10 each): mice with PEMF exposure and mice with sham PEMF exposure. PEMF (75 Hz, 3.8 mT, 1 h\/day) or sham PEMF was applied for 4 weeks. Pain behavior of mice, histological assessment of cartilage and synovium, micro-CT (computed tomography) analysis of bone, real-time polymerase chain reaction, and immunohistochemical staining of cartilage were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After DMM surgery, PEMF had a beneficial effect on pain, cartilage degeneration, synovitis, and trabecular bone microarchitecture in WT mice; these protective effects were reduced in IL-6\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      and TNF-\u03b1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice. In addition, PEMF downregulated IL-6 and TNF-\u03b1 expression in cartilage. PEMF also ameliorated cartilage matrix, chondrocyte apoptosis, and autophagy, while deletion of IL-6 or TNF-\u03b1 suppressed the effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PEMF attenuates structural and functional progression of OA through inhibition of TNF-\u03b1 and IL-6 signaling. The protective effects of PEMF on chondrocyte apoptosis and autophagy are regulated by TNF-\u03b1 and IL-6 signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035211049561","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T17:11:53Z","timestamp":1633626713000},"page":"1665S-1675S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Pulsed Electromagnetic Field Attenuates Osteoarthritis Progression in a Murine Destabilization-Induced Model through Inhibition of TNF-\u03b1 and IL-6 Signaling"],"prefix":"10.1177","volume":"13","author":[{"given":"Xiaotian","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of 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