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Acellular preparation methods as well as approaches to coax endogenous reparative cells into the joint space appear to have limited success. Supported by our in-vitro and clinical studies, we propose that our novel intra-articular administration of human granulocyte colony stimulating factor (IA-hG-CSF) combined with autologous activated peripheral blood stem cells (AAPBSC) is safe and offers treatment advantages not seen with other cellular interventions in early osteoarthritis.<\/jats:p>","DOI":"10.1177\/19476035211049562","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T18:19:08Z","timestamp":1634062748000},"page":"1671S-1674S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel Use of Intraarticular Granulocyte Colony Stimulating Factor (hG-CSF) Combined with Activated Autologous Peripheral Blood Stem Cells Mobilized with Systemic hG-CSF: Safe and Efficient in Early Osteoarthritis"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0041-7853","authenticated-orcid":false,"given":"Konstantinos I.","family":"Papadopoulos","sequence":"first","affiliation":[{"name":"THAI StemLife, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3732-9438","authenticated-orcid":false,"given":"Mantana","family":"Paisan","sequence":"additional","affiliation":[{"name":"THAI StemLife, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warachaya","family":"Sutheesophon","sequence":"additional","affiliation":[{"name":"THAI StemLife, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thana","family":"Turajane","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Police General Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"bibr1-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24008"},{"issue":"5","key":"bibr2-19476035211049562","volume":"96","author":"Turajane T","year":"2013","journal-title":"J Med Assoc Thai"},{"key":"bibr3-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1007\/s12306-013-0303-y"},{"key":"bibr4-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8925132"},{"key":"bibr5-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1177\/19476035211021905"},{"key":"bibr6-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1177\/1947603514520628"},{"key":"bibr7-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.63.BJR-2016-0083"},{"key":"bibr8-19476035211049562","doi-asserted-by":"publisher","DOI":"10.17265\/2159-5313\/2016.09.003"},{"key":"bibr9-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520909397"},{"key":"bibr10-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2017.02.117"},{"key":"bibr11-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006810.pub3"},{"key":"bibr12-19476035211049562","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.5006"},{"key":"bibr13-19476035211049562","doi-asserted-by":"publisher","DOI":"10.5603\/FHC.a2021.0017"},{"key":"bibr14-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-020-00201-3"},{"key":"bibr15-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2020.04.011"},{"key":"bibr16-19476035211049562","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-019-02366-x"},{"key":"bibr17-19476035211049562","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00404"}],"container-title":["CARTILAGE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035211049562","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19476035211049562","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035211049562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:02:42Z","timestamp":1777384962000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19476035211049562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,12]]},"references-count":17,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1177\/19476035211049562"],"URL":"https:\/\/doi.org\/10.1177\/19476035211049562","relation":{},"ISSN":["1947-6035","1947-6043"],"issn-type":[{"value":"1947-6035","type":"print"},{"value":"1947-6043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,12]]}}}