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Previous research has primarily focused on the link between peak loading during the loading phase of stance and joint tissue changes following anterior cruciate ligament reconstruction (ACLR). However, the associations between loading and cartilage composition at other portions of stance, including midstance and late stance, is unclear. The objective of this study was to explore associations between vertical ground reaction force (vGRF) at each 1% increment of stance phase and tibiofemoral articular cartilage magnetic resonance imaging (MRI) T1\u03c1 relaxation times following ACLR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Twenty-three individuals (47.82% female, 22.1 \u00b14.1 years old) with unilateral ACLR participated in a gait assessment and T1\u03c1 MRI collection at 12.25 \u00b1 0.61 months post-ACLR. T1\u03c1 relaxation times were calculated for the articular cartilage of the weightbearing medial and lateral femoral (MFC, LFC) and tibial (MTC, LTC) condyles. Separate bivariate, Pearson product moment correlation coefficients (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      ) were used to estimate strength of associations between T1\u03c1 MRI relaxation times in the medial and lateral tibiofemoral articular cartilage with vGRF across the entire stance phase.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Greater vGRF during midstance (46%-56% of stance phase) was associated with greater T1\u03c1 MRI relaxation times in the MFC (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      ranging between 0.43 and 0.46).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Biomechanical gait profiles that include greater vGRF during midstance are associated with MRI estimates of lesser proteoglycan density in the MFC. Inability to unload the ACLR limb during midstance may be linked to joint tissue changes associated with PTOA development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035211072220","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T06:03:29Z","timestamp":1643609009000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Loading during Midstance of Gait Is Associated with Magnetic Resonance Imaging of Cartilage Composition Following Anterior Cruciate Ligament Reconstruction"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8824-9366","authenticated-orcid":false,"given":"Elizabeth","family":"Bjornsen","sequence":"first","affiliation":[{"name":"Human Movement Science Curriculum, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0232-2543","authenticated-orcid":false,"given":"Todd A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1771-5734","authenticated-orcid":false,"given":"Caroline","family":"Lisee","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy","family":"Blackburn","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lalush","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nissman","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Spang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Pietrosimone","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2018.09.024."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23477."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22773."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515608475."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23534."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517723007."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517739605."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2020.105014."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2018.05.043."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.9509."},{"issue":"1107","key":"e_1_3_2_12_2","article-title":"Force actions transmitted by joints in the human body","volume":"192","author":"Paul JP.","year":"1976","unstructured":"Paul JP. 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