{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:25:51Z","timestamp":1793312751454,"version":"4.5.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Youth Program of National Natural Science Foundation of China","award":["32000926"],"award-info":[{"award-number":["32000926"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870972"],"award-info":[{"award-number":["81870972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Sailing Program","award":["20YF1435600"],"award-info":[{"award-number":["20YF1435600"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Developmental dysplasia of the hip (DDH) is the most common skeletal development in children and could result in secondary osteoarthritis. This study aims to clarify the alternations of subchondral trabecular bone remodeling and microstructural properties during the development of DDH, and the potential influence of these alternations on the overlying cartilage degeneration and DDH progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Traditional straight-leg swaddling method was adopted to establish DDH model in newborn Sprague Dawley rats. Hip joint specimens from normal or DDH rats were used. Typical features of DDH in radiological examination were observed by x-ray analysis. Micro\u2013computed tomography analysis was applied to evaluate the microstructural properties of subchondral bone at postnatal weeks 2, 4, and 6. Histological and immunohistochemical analyses were adopted to appraise subchondral bone remodeling activity and cartilage degeneration. The associations among subchondral bone, articular cartilage, and DDH severity were analyzed via multiple linear regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with control group, the subchondral bone in DDH group displayed a gradual trend of deteriorated microstructure and worsening biomechanical properties along with aberrant bone remodeling, which might be responsible for the inhibition of stress transmission from the articular cartilage to the subchondral bone and thus leading to the cartilage degeneration and accelerated DDH progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that alternations of subchondral trabecular bone in a time-dependent manner could contribute to the DDH progression and the amelioration on subchondral bone might be a favorable therapeutic candidate for DDH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035221098165","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T17:14:09Z","timestamp":1652894049000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Early Emergent and Progressive Aberrant Subchondral Bone Remodeling Coupled with Aggravated Cartilage Degeneration in Developmental Dysplasia of the Hip"],"prefix":"10.1177","volume":"13","author":[{"given":"Teng","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bizeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-2967","authenticated-orcid":false,"given":"Linyang","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.O.00109."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603521990859."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.05.033."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.67.Bjr-2016-0094.R1."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57431-x."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.206357."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.K.00779."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.07.004."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.101.Bjr-2020-0161.R1."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-1790-z."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3313."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25982."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2016.11.002."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/19476035211043202."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060716."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3909."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2019.09.001."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.K.00720."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2012.700346."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23828."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.07.014."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2017.02.003."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.124586."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4405."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.08.016."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.03.006."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-339."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2014.03.005."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2017.34."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2020.05.006."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090822."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21948-0."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.617200."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519878479."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218089."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.607764."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1979."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2222."},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.22203\/ecm.v024a20."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.10.013."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.320."},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.12.015."}],"container-title":["CARTILAGE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035221098165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19476035221098165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035221098165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:58:54Z","timestamp":1777384734000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19476035221098165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/19476035221098165"],"URL":"https:\/\/doi.org\/10.1177\/19476035221098165","relation":{},"ISSN":["1947-6035","1947-6043"],"issn-type":[{"value":"1947-6035","type":"print"},{"value":"1947-6043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"article-number":"19476035221098165"}}