{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:45:24Z","timestamp":1789098324210,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["N01-AR-2-2258"],"award-info":[{"award-number":["N01-AR-2-2258"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["N01-AR-2-2259"],"award-info":[{"award-number":["N01-AR-2-2259"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["N01-AR-2-2260"],"award-info":[{"award-number":["N01-AR-2-2260"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["N01-AR-2-2261"],"award-info":[{"award-number":["N01-AR-2-2261"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["N01-AR-2-2262"],"award-info":[{"award-number":["N01-AR-2-2262"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the association of worsening of magnetic resonance imaging (MRI) semi-quantitative (SQ) tissue features with concurrent change in quantitative (Q) cartilage thickness measurements over 24 months within the Foundation for the National Institutes of Health (FNIH) Biomarker Consortium study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In all, 599 participants were included. SQ assessment included cartilage damage, meniscal extrusion and damage, osteophytes, bone marrow lesions (BMLs), and effusion- and Hoffa-synovitis. Change in medial compartment Q cartilage thickness was stratified by concurrent ipsicompartmental SQ changes. Between-group comparisons were performed using analysis of covariance (ANCOVA) with adjustment for age, sex, and body mass index (BMI). Results were presented as adjusted mean difference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Knees with any increase in SQ cartilage scores in the medial compartment ( n = 268) showed more Q cartilage loss compared to knees that remained stable (mean adjusted difference [MAD] = -0.16 mm, 95% confidence interval [CI]: [-0.19, -0.13] mm). Knees with any increase in meniscal extrusion in the medial compartment (n = 98) showed more Q cartilage loss than knees without (MAD = -0.18 mm, 95% CI: [-0.22, -0.14] mm. Comparable findings were seen for meniscal damage worsening. Regarding BMLs, an increase by one subregion resulted in a MAD of Q cartilage loss of -0.10 mm, 95% CI: [-0.14, -0.06] mm, while this effect almost tripled for change in two or more subregions. Increase in either effusion- and\/or Hoffa-synovitis by one grade resulted in a MAD of -0.07 mm, 95% CI: [-0.10, -0.03] mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Worsening of SQ cartilage damage, meniscal extrusion and damage, number of subregions affected by BML, maximum size of BMLs and worsening of effusion- and\/or Hoffa synovitis is associated with increased Q cartilage loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035221147677","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T02:16:22Z","timestamp":1673316982000},"page":"39-47","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Worsening of Articular Tissue Damage as Defined by Semi-Quantitative MRI Is Associated With Concurrent Quantitative Cartilage Loss Over 24 Months"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-7350","authenticated-orcid":false,"given":"Frank","family":"Roemer","sequence":"first","affiliation":[{"name":"Friedrich-Alexander-Universitat Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Maschek","sequence":"additional","affiliation":[{"name":"Paracelsus Medizinische Privatuniversit\u00e4t, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wisser","sequence":"additional","affiliation":[{"name":"Paracelsus Medizinische Privatuniversit\u00e4t, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Boston Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hunter","sequence":"additional","affiliation":[{"name":"The University of Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2014-8278","authenticated-orcid":false,"given":"Felix","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Paracelsus Medizinische Privatuniversit\u00e4t, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wirth","sequence":"additional","affiliation":[{"name":"Paracelsus Medizinische Privatuniversit\u00e4t, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"bibr1-19476035221147677","doi-asserted-by":"publisher","DOI":"10.1002\/art.39731"},{"key":"bibr2-19476035221147677","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.06.017"},{"key":"bibr3-19476035221147677","doi-asserted-by":"publisher","DOI":"10.1186\/ar3209"},{"key":"bibr4-19476035221147677","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.14735"},{"key":"bibr5-19476035221147677","doi-asserted-by":"publisher","DOI":"10.1080\/14728214.2018.1547706"},{"key":"bibr6-19476035221147677","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.223"},{"key":"bibr7-19476035221147677","doi-asserted-by":"publisher","DOI":"10.1002\/art.39970"},{"key":"bibr8-19476035221147677","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.07.012"},{"key":"bibr9-19476035221147677","unstructured":"Osteoarthritis Initiative: A Knee Health Study\n                      . 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