{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:02:07Z","timestamp":1777478527620,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR071335-01"],"award-info":[{"award-number":["R01AR071335-01"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR071431"],"award-info":[{"award-number":["R01AR071431"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Hyaline cartilage has limited innate healing abilities and hyaline cartilage loss is a hallmark of osteoarthritis (OA). Animal models can provide important insights into cartilage regeneration potential. One such animal model, the African spiny mouse (\n                      <jats:italic toggle=\"yes\">Acomys<\/jats:italic>\n                      ), is capable of regenerating skin, skeletal muscle, and elastic cartilage. This study aims to evaluate whether these regenerative abilities protect\n                      <jats:italic toggle=\"yes\">Acomys<\/jats:italic>\n                      with meniscal injury from OA-related joint damage and behaviors indicative of joint pain and dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Acomys<\/jats:italic>\n                      received destabilization of the medial meniscus (DMM) surgery (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 11) or a skin incision (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 10). Gait testing occurred at 4, 6, 8, 10, and 12 weeks after surgery. At endpoint, joints were processed for histology to assess cartilage damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following joint injury,\n                      <jats:italic toggle=\"yes\">Acomys<\/jats:italic>\n                      with DMM surgery altered their walking patterns by increasing the percent stance time on the contralateral limb relative to the operated limb, thereby reducing the amount of time the injured limb must bear weight on its own throughout the gait cycle. Histological grading indicated evidence of OA-related joint damage in\n                      <jats:italic toggle=\"yes\">Acomys<\/jats:italic>\n                      with DMM surgery; these changes were primarily driven by loss of structural integrity in the hyaline cartilage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Acomys<\/jats:italic>\n                      developed gait compensations, and the hyaline cartilage in\n                      <jats:italic toggle=\"yes\">Acomys<\/jats:italic>\n                      is not fully protected from OA-related joint damage following meniscal injury, although this damage was less severe than that historically found in C57BL\/6 mice with an identical injury. Thus,\n                      <jats:italic toggle=\"yes\">Acomys<\/jats:italic>\n                      do not appear to be completely protected from OA-related changes, despite the ability to regenerate other wounded tissues.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035221149146","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:32:05Z","timestamp":1676680325000},"page":"94-105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["African Spiny Mice (\n                    <i>Acomys<\/i>\n                    ) Exhibit Mild Osteoarthritis Following Meniscal Injury"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4848-699X","authenticated-orcid":false,"given":"Kiara M.","family":"Chan","sequence":"first","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2689-9443","authenticated-orcid":false,"given":"Nat A.","family":"Thurlow","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Maden","sequence":"additional","affiliation":[{"name":"Department of Biology &amp; UF Genetics Institute, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle D.","family":"Allen","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA"},{"name":"Department of Orthopedics and Sports Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.72"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(97)80020-9."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-9-116"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34646"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2008.05.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1941738109350438."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2655."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34453"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1941738115611350"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.12.015"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2020.0244"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/CLIN.1998.4519."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/S11515-012-1192-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802132RR"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-020-00111-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11499"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.50"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27178-7"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01257907."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00400.2004"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.07.041"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28134-1"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-014-0456-x."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.03.008."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/JOR.20331."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0791-2"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.25306"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24623"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13847"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216228"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0142931"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.030"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.025"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.03.006."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-018-21184-5"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.90.8.3433"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/OXFORDJOURNALS.MOLBEV.A025567."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/19476035211053821"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.02.725"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.03.014"},{"key":"e_1_3_2_42_2","first-page":"4","article-title":"Managing a colony of spiny mice (Acomys cahirinus)","volume":"20","author":"Dickinson H","year":"2007","unstructured":"Dickinson H, Walker D. Managing a colony of spiny mice (Acomys cahirinus). Austral N Zeal Council Care Anim Res Train News. 2007;20:4-11.","journal-title":"Austral N Zeal Council Care Anim Res Train News"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/0023677218769921"}],"container-title":["CARTILAGE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035221149146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19476035221149146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035221149146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:02:58Z","timestamp":1777384978000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19476035221149146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1177\/19476035221149146"],"URL":"https:\/\/doi.org\/10.1177\/19476035221149146","relation":{},"ISSN":["1947-6035","1947-6043"],"issn-type":[{"value":"1947-6035","type":"print"},{"value":"1947-6043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]}}}