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This process concluded with a statement for each topic reflecting the best scientific evidence available for a particular diagnostic or therapeutic concept, including the grade of recommendation. Besides the scientific evidence, all group members rated the statements to identify possible gaps between literature and current clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with minimal symptoms, OLT progression to ankle osteoarthritis is unlikely. Risk factors for progression are the depth of the lesion on MRI, subchondral cyst formation, and the extent of bone marrow edema. Conservative management is the adaptation of activities to the performance of the ankle joint. A follow-up imaging after 12 months helps not to miss any progression. It is impossible to estimate the probability of success of conservative management from initial symptoms and imaging. Cast immobilization is an option in OLTs in children, with a success rate of approximately 50%, although complete healing, estimated from imaging, is rare. In adults, improvement by conservative management ranges between 45% and 59%. Rest and restrictions for sports activities seem to be more successful than immobilization. Intra-articular injections of hyaluronic acid and platelet-rich plasma can improve pain and functional scores for more than 6 months. If 3 months of conservative management does not improve symptoms, surgery can be recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035231161806","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T05:22:16Z","timestamp":1682054536000},"page":"292-304","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Etiology, Classification, Diagnostics, and Conservative Management of Osteochondral Lesions of the Talus. 2023 Recommendations of the Working Group \u201cClinical Tissue Regeneration\u201d of the German Society of Orthopedics and Traumatology"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-1303","authenticated-orcid":false,"given":"Markus","family":"Walther","sequence":"first","affiliation":[{"name":"Sch\u00f6n Klinik M\u00fcnchen Harlaching, FIFA Medical Centre of Excellence, Munich, Germany"},{"name":"Department of Orthopeadics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, Ludwig Maximilian University Munich, Munich, Germany"},{"name":"K\u00f6nig-Ludwig-Haus, Julius Maximilian University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Paracelsus Medizinische Privatuniversit\u00e4t, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6512-6275","authenticated-orcid":false,"given":"Oliver","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Sch\u00f6n Klinik M\u00fcnchen Harlaching, FIFA Medical Centre of Excellence, Munich, Germany"},{"name":"Department of Orthopeadics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Madry","sequence":"additional","affiliation":[{"name":"Institute of Experimental Orthopaedics and Department of Orthopaedic Surgery, Saarland University, Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Orthopeadics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2287-1654","authenticated-orcid":false,"given":"Matthias","family":"Steinwachs","sequence":"additional","affiliation":[{"name":"SportClinic Z\u00fcrich, Klinik Hirslanden, Z\u00fcrich, Switzerland"},{"name":"ETH Z\u00fcrich, Z\u00fcrich, Switzerland"},{"name":"Albert-Ludwigs-Universit\u00e4t Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"Albert-Ludwigs-Universit\u00e4t Freiburg, Freiburg, Germany"},{"name":"OCM\u2014Hospital for Orthopedic Surgery Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Niethammer","sequence":"additional","affiliation":[{"name":"Department of Orthopeadics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tischer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Malteser Waldkrankenhaus St. Marien, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Petersen","sequence":"additional","affiliation":[{"name":"OTC-Alstertal, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Feil","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Unfallchirurgie und Orthop\u00e4die, Kath. 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