{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:09:47Z","timestamp":1783523387071,"version":"3.55.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174368"],"award-info":[{"award-number":["82174368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030312009"],"award-info":[{"award-number":["2017A030312009"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Functional polymorphisms of interleukin 16 (IL16) have been reported to be closely related to the risk of osteoarthritis (OA). However, how IL16 affects OA remains unclear. In this study, the role of IL16 in OA and the possible mechanisms were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We established a meniscal\/ligament injury (MLI) post-traumatic OA model in Sprague Dawley rats and an IL1\u03b2-induced ADTC5 cells OA model. We detected the expression of IL16, novel-miR-81, MMP3, and MMP13 by quantitative real-time polymerase chain reaction. Western blot was performed to detect the expression of IL16, MMP3, and MMP13. The association between IL16 and novel-miR-81 was confirmed by luciferase reporter assay. Hematoxylin and eosin staining, Safranin O and Fast Green staining, and immunohistochemical staining were performed to clarify the effect of intra-articular injection of novel-miR-81 agomir in rats OA model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IL16 was upregulated in OA model. Knockdown of IL16 and overexpression of novel-miR-81 downregulated the expression of MMP3 and MMP13. Importantly, IL16 was a key target of novel-miR-81. Intra-articular injection of novel-miR-81 agomir could attenuate OA progression in rats OA model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Novel-miR-81 targeted IL16 to relieve OA, suggesting that novel-miR-81and IL16 may be new therapeutic targets for OA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035231168387","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T01:42:58Z","timestamp":1682127778000},"page":"175-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-4150","authenticated-orcid":false,"given":"Ziwei","family":"Luo","sequence":"first","affiliation":[{"name":"Research Centre of Basic Intergrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China"},{"name":"Traditional Chinese Medicine Innovation Research Center, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3984-3101","authenticated-orcid":false,"given":"Qianting","family":"Han","sequence":"additional","affiliation":[{"name":"Research Centre of Basic Intergrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Lu","sequence":"additional","affiliation":[{"name":"Research Centre of Basic Intergrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyan","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Research Centre of Basic Intergrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueying","family":"Fan","sequence":"additional","affiliation":[{"name":"Research Centre of Basic Intergrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangping","family":"Liu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Innovation Research Center, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Experimental Teaching, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiechen","family":"Kong","sequence":"additional","affiliation":[{"name":"Center for Experimental Teaching, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helu","family":"Liu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Innovation Research Center, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Centre of Basic Intergrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Centre of Basic Intergrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"bibr1-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.11.010"},{"key":"bibr2-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.136"},{"key":"bibr3-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"bibr4-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6338"},{"issue":"5","key":"bibr5-19476035231168387","volume":"5","author":"Puljak L","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr6-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1535-9"},{"key":"bibr7-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24457"},{"key":"bibr8-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.01.016"},{"issue":"1","key":"bibr9-19476035231168387","volume":"8","author":"Liu Z","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"bibr10-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123442"},{"key":"bibr11-19476035231168387","doi-asserted-by":"crossref","unstructured":"Cao Y, Tang S, Nie X, Zhou Z, Ruan G, Han W, et al. Decreased miR-214-3p activates NF-\u03baB pathway and aggravates osteoarthritis progression. EBioMedicine. 2021;65:103283.","DOI":"10.1016\/j.ebiom.2021.103283"},{"key":"bibr12-19476035231168387","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.703670"},{"key":"bibr13-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12787"},{"key":"bibr14-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1028-2_6"},{"key":"bibr15-19476035231168387","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-2068"},{"key":"bibr16-19476035231168387","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27715"},{"key":"bibr17-19476035231168387","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2019.84811"},{"key":"bibr18-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.12.002"},{"key":"bibr19-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0045-7"},{"key":"bibr20-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.07.011"},{"key":"bibr21-19476035231168387","volume":"37","author":"Swingler TE","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"bibr22-19476035231168387","doi-asserted-by":"publisher","DOI":"10.3390\/cells7080092"},{"key":"bibr23-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.10.032"},{"key":"bibr24-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1002\/art.41552"},{"key":"bibr25-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30361"},{"key":"bibr26-19476035231168387","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0411-x"}],"container-title":["CARTILAGE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035231168387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19476035231168387","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035231168387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:05Z","timestamp":1777384985000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19476035231168387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/19476035231168387"],"URL":"https:\/\/doi.org\/10.1177\/19476035231168387","relation":{},"ISSN":["1947-6035","1947-6043"],"issn-type":[{"value":"1947-6035","type":"print"},{"value":"1947-6043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,21]]}}}