{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:26:51Z","timestamp":1791872811995,"version":"4.3.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371997"],"award-info":[{"award-number":["81371997"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018853","name":"Prince Charles Hospital Foundation","doi-asserted-by":"publisher","award":["RF-01"],"award-info":[{"award-number":["RF-01"]}],"id":[{"id":"10.13039\/501100018853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1176298"],"award-info":[{"award-number":["APP1176298"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2015JC3034"],"award-info":[{"award-number":["2015JC3034"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2018JJ2579"],"award-info":[{"award-number":["2018JJ2579"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Chronic inflammation plays an important role in the osteoarthritis (OA) pathology but how this influence OA disease progression is unclear. Leukotriene B4 (LTB\n                      <jats:sub>4<\/jats:sub>\n                      ) is a potent proinflammatory lipid mediator generated from arachidonic acid through the sequential activities of 5-lipoxygenase, 5-lipoxygenase\u2013activating protein, Leukotriene A\n                      <jats:sub>4<\/jats:sub>\n                      hydrolase (LTA\n                      <jats:sub>4<\/jats:sub>\n                      H) and its downstream product LTB\n                      <jats:sub>4<\/jats:sub>\n                      . The aim of this study is to investigate the involvement and the potential therapeutic target of the LTB\n                      <jats:sub>4<\/jats:sub>\n                      pathway in OA disease progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Both clinical human cartilage samples ( n = 7) and mice experimental OA models ( n = 6) were used. The levels of LTA\n                      <jats:sub>4<\/jats:sub>\n                      H and leukotriene B4 receptor 1 were first examined using immunostaining in human OA\/non-OA cartilage and mice experimental OA models. We also determined whether the LTA\n                      <jats:sub>4<\/jats:sub>\n                      H pathway was associated with cartilage degeneration and synovitis inflammation in OA mice models and human articular chondrocytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that both LTA\n                      <jats:sub>4<\/jats:sub>\n                      H and LTB\n                      <jats:sub>4<\/jats:sub>\n                      receptor (BLT1) were highly expressed in human and mice OA cartilage. Inhibition of LTA\n                      <jats:sub>4<\/jats:sub>\n                      H suppressed cartilage degeneration and synovitis in OA mice model. Furthermore, inhibition of LTA\n                      <jats:sub>4<\/jats:sub>\n                      H promoted cartilage regeneration by upregulating chondrogenic genes expression such as aggrecan ( ACAN), collagen 2A1 ( COL2A1), and SRY-Box transcription factor 9 ( SOX9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our results indicate that the LTA\n                      <jats:sub>4<\/jats:sub>\n                      H pathway is a crucial regulator of OA pathogenesis and suggest that LTA\n                      <jats:sub>4<\/jats:sub>\n                      H could be a therapeutic target in combat OA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035231169940","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T01:45:43Z","timestamp":1682127943000},"page":"184-194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Inhibition of Leukotriene A\n                    <sub>4<\/sub>\n                    Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis"],"prefix":"10.1177","volume":"15","author":[{"given":"Xiaoxin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China"},{"name":"Centre for Biomedical Technologies, Faculty of Science and Engineering, Queensland University of Technology, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia RuJia","family":"Sun","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Technologies, Faculty of Science and Engineering, Queensland University of Technology, Brisbane, QLD, Australia"},{"name":"School of Medicine and Dentistry, Griffith University, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Crawford","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Technologies, Faculty of Science and Engineering, Queensland University of Technology, Brisbane, QLD, Australia"},{"name":"Orthopaedic Department, The Prince Charles Hospital, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University, Brisbane, QLD, Australia"},{"name":"Australia-China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Wang","sequence":"additional","affiliation":[{"name":"Health Management Center, The Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Prasadam","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Technologies, Faculty of Science and Engineering, Queensland University of Technology, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-6043","authenticated-orcid":false,"given":"Xinzhan","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"issue":"9","key":"bibr1-19476035231169940","volume":"81","author":"Woolf AD","year":"2003","journal-title":"Bull World Health Organ"},{"key":"bibr2-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205003"},{"key":"bibr3-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.03.014"},{"key":"bibr4-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36909-9"},{"key":"bibr5-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.01.018"},{"key":"bibr6-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5548.1871"},{"key":"bibr7-19476035231169940","volume":"16","author":"Abdellatif KR","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"bibr8-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1126\/science.6301011"},{"key":"bibr9-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-014-0292-7"},{"key":"bibr10-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005568"},{"key":"bibr11-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2011.08.004"},{"key":"bibr12-19476035231169940","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-9-199411010-00010"},{"key":"bibr13-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006674"},{"key":"bibr14-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1038\/srep44449"},{"key":"bibr15-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088423"},{"key":"bibr16-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(03)00073-5"},{"key":"bibr17-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.39"},{"key":"bibr18-19476035231169940","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.6254"},{"key":"bibr19-19476035231169940","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100196"},{"key":"bibr20-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1002\/art.10357"},{"issue":"8","key":"bibr21-19476035231169940","volume":"30","author":"Hashimoto A","year":"2003","journal-title":"J Rheumatol"},{"key":"bibr22-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12275"},{"key":"bibr23-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199809)41:9<1645::AID-ART16>3.0.CO;2-Z"},{"key":"bibr24-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101449R"},{"key":"bibr25-19476035231169940","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.628843"},{"key":"bibr26-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.14.1053"},{"key":"bibr27-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.05.008"},{"key":"bibr28-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.03.032"},{"key":"bibr29-19476035231169940","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020251"},{"key":"bibr30-19476035231169940","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.734988"},{"key":"bibr31-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054633"},{"key":"bibr32-19476035231169940","first-page":"3930826","volume":"2021","author":"Li H","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"bibr33-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117242"},{"key":"bibr34-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.8.605"},{"key":"bibr35-19476035231169940","doi-asserted-by":"publisher","DOI":"10.2174\/1389200013338748"},{"key":"bibr36-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1007\/BF00205797"},{"key":"bibr37-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1002\/art.27397"},{"key":"bibr38-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183693"},{"key":"bibr39-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111965"},{"key":"bibr40-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker360"},{"key":"bibr41-19476035231169940","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110777"},{"key":"bibr42-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu262"},{"key":"bibr43-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.08.157"},{"key":"bibr44-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328349c2b1"},{"key":"bibr45-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1038\/nri2294"},{"key":"bibr46-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90350"},{"key":"bibr47-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071371"},{"issue":"3","key":"bibr48-19476035231169940","volume":"29","author":"He W","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr49-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20864"},{"key":"bibr50-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)44:10<2320::AID-ART394>3.0.CO;2-P"},{"key":"bibr51-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1002\/art.20632"},{"issue":"2","key":"bibr52-19476035231169940","first-page":"99","volume":"70","author":"Attur M","year":"2012","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"bibr53-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.07.018"},{"key":"bibr54-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209168"},{"key":"bibr55-19476035231169940","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.91"},{"key":"bibr56-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062554"},{"key":"bibr57-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.371"},{"key":"bibr58-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216614"},{"key":"bibr59-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA03787F"},{"key":"bibr60-19476035231169940","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024407"}],"container-title":["CARTILAGE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035231169940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/19476035231169940","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/19476035231169940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:05Z","timestamp":1777384985000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/19476035231169940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/19476035231169940"],"URL":"https:\/\/doi.org\/10.1177\/19476035231169940","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-1245437\/v1","asserted-by":"object"}]},"ISSN":["1947-6035","1947-6043"],"issn-type":[{"value":"1947-6035","type":"print"},{"value":"1947-6043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,21]]}}}