{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:02:37Z","timestamp":1777478557541,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Mechanical alignment of the lower limbs has been suggested to cause abnormal uneven loading across the compartments at the knee, but its contribution to the initiation and progression of arthritis remains controversial. This study aimed to establish whether malalignment of the lower limb after trauma is associated with worsened arthritis scores in the theoretically overloaded compartment, and if arthritis scores continuously correlate with the degree of malalignment and time with deformity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>After screening 1160 X-rays, 60 patients were identified with long-leg radiographs &gt; 2 years after fracture. Measurement of mechanical axis deviation (MAD) divided into groups of varus malalignment ( n = 16, &gt;16 mm), valgus ( n = 25, &lt;0 mm), and normal alignment ( n = 19). Alignment and bilateral knee compartmental arthritis scores were recorded by three clinicians, compared via analysis of variance and assessed with linear regression against time since injury using MAD as a covariate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In varus and valgus malalignment, there was a greater mean arthritis score in the \u201coverloaded\u201d compartment compared to the contralateral side, with varus medial Osteoarthritis Research Society International (OARSI) scores 5.17 \u00b1 2.91 vs 3.50 \u00b1 2.72 ( P = 0.006) and Kellegren-Lawrence scores 2.65 \u00b1 1.19 vs 1.79 \u00b1 1.24 ( P \u2264 0.001). In a linear regression model, OARSI arthritis score was significantly associated with absolute MAD (0.6\/10 mm MAD, P &lt; 0.001) and time (0.7\/decade, P \u2264 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Malalignment consistently results in more advanced arthritis scores in the overloaded compartment, most likely related to abnormal loading across the knee. Severity of arthritis using OARSI grading continuously correlates with degree of malalignment and time with deformity after post-traumatic malunion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035231186688","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T04:19:12Z","timestamp":1697516352000},"page":"100-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Asymmetric Post-Traumatic Knee Arthritis Is Closely Correlated With Both Severity and Time for Lower Limb Coronal Plane Malalignment"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-0805","authenticated-orcid":false,"given":"Luke E.","family":"Visscher","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Royal Brisbane and Women\u2019s Hospital, Brisbane, QLD, Australia"},{"name":"Queensland University of Technology, Brisbane, QLD, Australia"},{"name":"Department of Surgery, School of Medicine, University of Queensland, Herston, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathal","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Royal Brisbane and Women\u2019s Hospital, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordy","family":"White","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Royal Brisbane and Women\u2019s Hospital, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3069-4141","authenticated-orcid":false,"given":"Kevin","family":"Tetsworth","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Royal Brisbane and Women\u2019s Hospital, Brisbane, QLD, Australia"},{"name":"Department of Surgery, School of Medicine, University of Queensland, Herston, QLD, Australia"},{"name":"Orthopaedic Research Centre of Australia, Brisbane, QLD, Australia"},{"name":"Herston Biofabrication Institute, Herston, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"bibr1-19476035231186688","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(20)31921-0"},{"key":"bibr2-19476035231186688","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198971040-00016"},{"key":"bibr3-19476035231186688","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199109000-00001."},{"issue":"280","key":"bibr4-19476035231186688","first-page":"48","author":"Paley D","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"bibr5-19476035231186688","first-page":"65","volume":"280","author":"Paley D","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"bibr6-19476035231186688","volume-title":"Principles of deformity 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