{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:02:38Z","timestamp":1777478558081,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to determine the level of disease severity in a pilot cohort of temporomandibular joints (TMJs) and compare them to the pathology findings previously characterized in cadaveric knee joints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Thirty-one intact TMJs from 17 cadaveric donors were harvested and arthritic lesioning seen in the knee joint was investigated on the condyle and the fossa of the TMJ. Prevalence of gross alterations was equated and disease severity was determined for sex- and age-based donor pools using a validated, osteoarthritis (OA) disease severity scale (DSS). Knee joint DSS scores were also compared to the TMJ condyle and fossa DSS scores and a case study was carried out on a male donor that demonstrated severe OA in the both joints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mandibular fossa demonstrated an increase in disease severity compared to the mandibular condyle in a mixed sex donor pool ( P = 0.035). It was discovered that the younger females demonstrated statistically more pathological condyles compared to the older half of the female subgroup ( P = 0.02). TMJ fossa and knee joints demonstrated comparable OA severity and similar signs of cartilage disease in a single donor highlighting the systemic nature of OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that gross signs of OA in the TMJs of cadavers are comparable to pathology found in the knee. The mandibular fossa appears to be the site of more profound disease, implying translational movements may be more likely to induce biomechanically abnormal movement, loading, and OA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035231189839","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T07:08:01Z","timestamp":1691478481000},"page":"445-454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Osteoarthritis Disease Severity in the Temporomandibular Joint and the Knee Joint: A Comparative Cadaveric Study"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7846-2238","authenticated-orcid":false,"given":"Jessica A.","family":"Immonen","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Ciccotelli","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, School of Integrated Health Science, University of Nevada, Las Vegas, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linh M.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley","family":"Gilmer","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Landen","family":"Broadhead","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mackenzie","family":"Kitchen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conner","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"James","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"bibr1-19476035231189839","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216515"},{"key":"bibr2-19476035231189839","unstructured":"Centers for Disease Control and Prevention. A national public health agenda for osteoarthritis. Arthiritis Foundation. [cited 2023 Jan 15]. Available from: https:\/\/www.cdc.gov\/arthritis\/docs\/oaagenda2020.pdf."},{"key":"bibr3-19476035231189839","doi-asserted-by":"publisher","DOI":"10.1002\/art.34453"},{"key":"bibr4-19476035231189839","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-014-9917-9"},{"key":"bibr5-19476035231189839","doi-asserted-by":"publisher","DOI":"10.1177\/1947603517713817"},{"key":"bibr6-19476035231189839","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(88)80074-4"},{"key":"bibr7-19476035231189839","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.06.015"},{"key":"bibr8-19476035231189839","unstructured":"Standring S. Gray\u2019s anatomy: the anatomical basis of clinical practice. 41st ed. 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