{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:59:06Z","timestamp":1780678746854,"version":"3.54.1"},"reference-count":46,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the prognostic factors for clinical outcomes and cartilage regeneration after the implantation of allogeneic human umbilical cord blood mesenchymal stem cell (hUCB-MSC) for treating large-sized cartilage defects with osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This study is a case-series with multiple subgroup analyses that divides the included patients into multiple subgroups based on various factors. Overall, 47 patients who underwent hUCB-MSC implantation were included. The patient-reported outcomes, magnetic resonance imaging (MRI), and second-look arthroscopy were used to assess the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Combined realignment surgery significantly correlated with clinical outcomes, particularly pain. No other factors significantly influenced the clinical outcomes in short-term period. Subgroups with large defect sizes or meniscal insufficiency showed significantly poor MRI and arthroscopy outcomes (MRI, P = 0.001, P = 0.001; arthroscopy, P = 0.032, P = 0.042). The logistic regression showed that patients with a 1 cm\n                      <jats:sup>2<\/jats:sup>\n                      larger defect size were 1.91 times less likely to achieve favorable MRI outcomes ( P = 0.017; odds ratio [OR], 1.91). Cut-off value to predict the poor outcome was &gt;5.7 cm\n                      <jats:sup>2<\/jats:sup>\n                      (area under the curve, 0.756). A cartilage defect size &gt;5.7 cm\n                      <jats:sup>2<\/jats:sup>\n                      was the major poor prognostic factor for cartilage regeneration on MRI ( P = 0.010; OR, 17.46). If the postoperative alignment shifted by 1\u00b0 opposite to the cartilage defect, it was 1.4 times more likely to achieve favorable MRI outcomes ( P = 0.028; OR, 1.4).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Combining realignment surgery showed a better prognosis for pain improvement. Cartilage defect size, meniscal function, and postoperative alignment are significant prognostic factors for cartilage regeneration. A cartilage defect size &gt;5.7 cm\n                      <jats:sup>2<\/jats:sup>\n                      was significantly related to poor cartilage regeneration.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035241231372","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:57:22Z","timestamp":1708131442000},"page":"375-388","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic Factors for Clinical Outcome and Cartilage Regeneration after Implantation of Allogeneic Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Large-Sized Cartilage Defects with Osteoarthritis"],"prefix":"10.1177","volume":"15","author":[{"given":"Se-Han","family":"Jung","sequence":"first","affiliation":[{"name":"Arthroscopy and Joint Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Department of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Hyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Arthroscopy and Joint Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Department of Orthopedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5743-6241","authenticated-orcid":false,"given":"Sung-Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Arthroscopy and Joint Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Department of Orthopedic Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of 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