{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:49:46Z","timestamp":1790650186265,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate how running, cycling, and sedentary cardiovascular stress impact biomarkers of cartilage turnover acutely in subjects with knee osteoarthritis (OA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This was a sequential, cross-over, clinical study. Forty subjects with primary knee OA underwent moderate-to-high-intensity cycling, running, and adrenaline infusion on separate days. Blood was sampled before, during, and at 6-time points after intervention. On a control day, similar samples were taken. Biomarkers of type II collagen degradation (C2M, T2CM, Coll2-1, Coll2-1NO2), formation (PRO-C2), and aggrecan degradation (ARGS) were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age was 60.4 years, 40% were male, 45% had cumulated Kellgren-Lawrence (KL)-grade (Right + Left knee) of 2 to 3 and 55% had 4 to 6. Analyzing overall changes, area under the curve was significantly lower compared with resting values for ARGS and C2M after cycling and for ARGS after running. Considering individual time points, peak changes in biomarker levels showed reduction in C2M shortly following cycling (T\n                      <jats:sub>20min<\/jats:sub>\n                      = \u221212.3%, 95% confidence interval [CI]: \u221219.3% to \u22125.2%). PRO-C2 increased during cycling (T\n                      <jats:sub>10min<\/jats:sub>\n                      = 14.0%, 95% CI = 4.1% to 23.8%) and running (T\n                      <jats:sub>20min<\/jats:sub>\n                      = 16.5%, 95% CI = 4.3% to 28.6%). T2CM decreased after cycling (T\n                      <jats:sub>50min<\/jats:sub>\n                      = \u221219.9%, 95% CI = \u221229.2% to \u221210.6%), running (T\n                      <jats:sub>50min<\/jats:sub>\n                      = \u221222.8%, 95% CI = \u221232.1% to \u221213.5%), and infusion of adrenaline (peak, T\n                      <jats:sub>50min<\/jats:sub>\n                      = \u22129.8%, 95% CI = \u221220.0% to 0.4%). A latent increase was seen in Coll2-1 240 minutes after running (T\n                      <jats:sub>260min<\/jats:sub>\n                      = 21.7%, 95% CI = \u22121.6% to 45.1%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exercise had an impact on cartilage markers, but it did not suggest any detrimental effect on cartilage. Changes following adrenaline infusion suggest a sympathomimetic influence on the serological composition of biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035241258170","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T01:09:50Z","timestamp":1717981790000},"page":"159-168","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Impact of Weight-bearing Exercise, Non\u2013Weight-bearing Exercise, and Cardiovascular Stress on Biochemical Markers of Cartilage Turnover in Patients With Mild to Moderate Knee Osteoarthritis \u2013 A Sequential, Cross-Over, Clinical Study"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6477-3219","authenticated-orcid":false,"given":"Jonathan J.","family":"Bjerre-Bastos","sequence":"first","affiliation":[{"name":"Xlab, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"},{"name":"NBCD A\/S, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper","family":"Sejersen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning Bay","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Anaesthesia and Intensive Care Medicine, Zealand University Hospital, Roskilde, Denmark"},{"name":"Department of Nutrition, Exercise and Sport, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Boesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Radiology, Bispebjerg and Frederiksberg Hospitals, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels H.","family":"Secher","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Distajo","sequence":"additional","affiliation":[{"name":"Prosoft Clinical, Wayne, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Flood","sequence":"additional","affiliation":[{"name":"Prosoft Clinical, Wayne, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Henrotin","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation, VIVALIA, Marche-en-Famenne, Belgium"},{"name":"Musculoskeletal Innovative Research Lab (mSKIL), University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Uebelhoer","sequence":"additional","affiliation":[{"name":"Artialis Group, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Krustrup","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl-Christian","family":"Kitchen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian S.","family":"Thudium","sequence":"additional","affiliation":[{"name":"Nordic Bioscience, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe R.","family":"Andersen","sequence":"additional","affiliation":[{"name":"NBCD A\/S, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger R.","family":"Bihlet","sequence":"additional","affiliation":[{"name":"NBCD A\/S, Herlev, 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