{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:09:04Z","timestamp":1790143744472,"version":"4.0.1"},"reference-count":55,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["105-2314-B-475-001, 106-2314-B-475-001, 107-2314-B"],"award-info":[{"award-number":["105-2314-B-475-001, 106-2314-B-475-001, 107-2314-B"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PingTung Christian","award":["PS103002, PS108003"],"award-info":[{"award-number":["PS103002, PS108003"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["CARTILAGE"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Mounting evidence suggests that histone deacetylases (HDAC) inhibitors reduce cartilage destruction in animal models of osteoarthritis (OA). Tumor necrosis factor (TNF)-\u03b1-blocking treatment for OA may provide effective joint protection by slowing joint damage. To investigate the effects of intraperitoneal administration of etanercept (a TNF-\u03b1 inhibitor) on OA development in rats and changes in the nociceptive behavior of rats and expression of HDACs, RUNX2, and MMP13 in cartilage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Induction of OA in Wistar rats was accomplished through anterior cruciate ligament transection (ACLT). One or five milligrams (mg) of etanercept was administered intraperitoneally for 5 consecutive weeks after ACLT to the ACLT + etanercept (1 and 5 mg\/kg) groups. Nociceptive behavior and changes in knee joint width were analyzed. Cartilage was evaluated histologically and immunohistochemically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ACLT + etanercept significantly improved mechanical allodynia and weight-bearing distribution compared to ACLT alone. In OA rats treated with etanercept, cartilage degeneration and synovitis were significantly less pronounced than those in ACLT rats. OA-affected cartilage also showed reduced expression of HDAC 6, 7, RUNX-2, and MMP-13 in response to etanercept but increased expression of HDAC4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrated that etanercept therapy (1) attenuated the development of OA and synovitis in rats, (2) reduced nociception, and (3) regulated chondrocyte metabolism, possibly by inhibiting cell HDAC6 and HDAC7, RUNX2, and MMP13 and increasing HDAC4 expression. Based on new evidence, etanercept may have therapeutic potential in OA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035241264012","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T08:51:10Z","timestamp":1721983870000},"page":"241-253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Etanercept on Experimental Osteoarthritis in Rats: Role of Histone Deacetylases"],"prefix":"10.1177","volume":"17","author":[{"given":"Zhi-Hong","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chieh","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Early Childhood Education, National Pintung University, Pingtung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-You","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Kang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan"},{"name":"Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Peng","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Section of Pathology, Pingtung Christian Hospital, Pingtung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Gar-Hwa-Lai","sequence":"additional","affiliation":[{"name":"Section of Orthopedic Surgery, Pingtung Veterans General Hospital, Pingtung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan"},{"name":"Department of Neurosurgery, College of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-5603","authenticated-orcid":false,"given":"Yen-Hsuan","family":"Jean","sequence":"additional","affiliation":[{"name":"Section of Orthopedic Surgery, Pingtung Christian Hospital, Pingtung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/JCMRP.JCMRP_99_19"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561459"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar326"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6117"},{"issue":"11","key":"e_1_3_2_7_2","article-title":"Does anti-tumour necrosis factor alpha therapy exert a long-term structural benefit in hand osteoarthritis","volume":"57","author":"Jorge ARB","year":"2018","unstructured":"Jorge ARB, Helen K, Gabriel H. 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